RHOB

Protein RHOB map

Identifiers
ras homolog family member B
HUGO:RHOB HGNC:668 ENTREZ:388 UNIPROT:P62745 GENECARDS:RHOB REACTOME:63082 KEGG:388 ATLASONC:RHOBID42108ch2p24 WIKI:RHOB

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / TIGHT_JUNCTIONS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:9822605
Members of the Rho/Rac family can be grouped into 3 classes according to amino acid sequence similarities.
The first subfamily is composed of four Rac proteins (Rac-1, Rac-2, Rac-3 and RhoG). Some of these proteins promote the activation of protein kinases such as PAK, c-Jun N-terminal kinase (JNK) and p38MAPK. They are also involved in the activation of other independent pathways regulating membrane ruffling and cell proliferation.
The second subfamily, Rho, includes RhoA, RhoB, RhoC, RhoD, RhoE and TTF proteins. RhoA has been characterized extensively and shown to be involved in cell transforma- tion, formation of stress fibers and focal adhesions, and in the stimulation of protein kinases such as PKN and p160Rock
Finally, the third subfamily is composed of TC10 and the two isoforms of the Cdc42 protein. Cdc42 was shown to be involved in the activation of JNK, PAK and p38MAPK as well as in the formation of filopodia in the plasma membrane


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. GDP:​RHOB@Cytoplasm map

  2. GTP:​RHOB@Cytoplasm map
  3. GTP:​RHOB:​RhoB_cytoskeletal_effectors*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. GTP:​RHOB@Cytoplasm map map GDP:​RHOB@Cytoplasm map

  2. GDP:​RHOB@Cytoplasm map map GTP:​RHOB@Cytoplasm map
  3. GTP:​RHOB:​RhoB_cytoskeletal_effectors*@Cytoplasm map map Cytoskeleton remodeling@Nucleus map
  4. GTP:​RHOB:​RhoB_cytoskeletal_effectors*@Cytoplasm map map Actin polymerization@Nucleus map
  5. RhoA_B*@Cytoplasm map map GTP:​RHOB@Cytoplasm map
  6. GTP:​RHOB@Cytoplasm map + RhoB_cytoskeletal_effectors*@Cytoplasm map map GTP:​RHOB:​RhoB_cytoskeletal_effectors*@Cytoplasm map

As Catalyser:

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