Repaired_DNA*

Gene Repaired_DNA* map

Identifiers
Ligated and repaired DNA
Node_Type:Generic

gRepaired_DNA*@Nucleus

References
d_re180( DNA repair  map ):
Phosphorylated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
PMID:17035102
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
PMID:19225445
REV1 interacts with many TLS polymerases:
PMID:14657033
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158,
For TLS PMID:19258535
d_re500:( DNA repair  map ) reactionType:is.a
d_re115( DNA repair  map ):
PMID:16581787,
For inhibition of S-checkpoint by ATM:
PMID:15175241
Inhibition of Sphase by MRE complex:
PMID:17713585
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
d_re119( DNA repair  map ):
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
PMID:19342888
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
PMID:16713580
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767
d_re120( DNA repair  map ):
By CycB*/CDC2*:
G2/M transition
PMID:16818604
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
PMID:15377654
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
PMID:15242590
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
PMID:18995830
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
PMID:14614141
d_re216( DNA repair  map ):
By CDC20/APC complex:
M to G1 transition
By Mitotic checkpoint complex:
Spindle checkpoint
PARP3 activated spindle checkpoint
PMID:21270334
Tankyrase activated spindle checkpoint
PMID:23197039
d_re437( DNA repair  map ):
Stalled replication forks induce PCNA mono-ubiquitylation and formation of the complex that activated TLS and arrests S-phase:
PMID:19793801, PMID:17582221, PMID:19158510, PMID:18451105


Modifications:
In compartment: Nucleus
  1. gRepaired_DNA*@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gDamaged_DNA*@Nucleus map map gRepaired_DNA*@Nucleus map

    2. gTC-NER_GG-NER_DNA_st6*@Nucleus map map gRepaired_DNA*@Nucleus map
    3. gShP_BER_M-glyc_st5_B-glyc_DNA_st6*@Nucleus map map gRepaired_DNA*@Nucleus map
    4. gLnP_BER_M-glyc_st6*@Nucleus map map gRepaired_DNA*@Nucleus map
    5. gMMR_DNA_st5*@Nucleus map map gRepaired_DNA*@Nucleus map
    6. gSSA_DNA_st6*@Nucleus map map gRepaired_DNA*@Nucleus map
    7. gC_NHEJ_DNA_st5*@Nucleus map map gRepaired_DNA*@Nucleus map
    8. gA_NHEJ_DNA_st6*@Nucleus map map gRepaired_DNA*@Nucleus map
    9. gHR_DNA_st7*@Nucleus map map gRepaired_DNA*@Nucleus map
    10. gTLS_DNA_st2*@Nucleus map map gRepaired_DNA*@Nucleus map
    11. gDR_DNA_st2*@Nucleus map map gRepaired_DNA*@Nucleus map

    As Catalyser:

    1. G1 phase@default map map S phase@default map

    2. S phase@default map map G2 phase@default map
    3. G2 phase@default map map M phase@default map
    4. M phase@default map map G1 phase@default map
    5. No DNA replicarion@default map map DNA replicarion@default map

    Leave a Reply