Gene Repaired_DNA* map

Ligated and repaired DNA


d_re180( DNA repair  map ):
Phosphorylated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
REV1 interacts with many TLS polymerases:
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158,
For TLS PMID:19258535
d_re500:( DNA repair  map ) reactionType:is.a
d_re115( DNA repair  map ):
For inhibition of S-checkpoint by ATM:
Inhibition of Sphase by MRE complex:
By CycE*/CDK2: G1/S transition
By CycD*/CDK2/CIp/KIP: checkpoint G1/S
d_re119( DNA repair  map ):
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767
d_re120( DNA repair  map ):
By CycB*/CDC2*:
G2/M transition
For BRCA2 and FANCD2/FANCDI importance in the cytokinesis and localisation at the spindle and role in the propagation of mitosis:
PMID:15375219, PMID:19686080
CDC2 has to be phosphorylated fot inhibition of G2 to M propagation (called G2 checkpoint). FANCC activates CDC2 phosphorylation
Brca1 ubiquitinates CtIp and in complex they inhibit G2 to M propagation (G2 checkpoint)
PMID:16818604, PMID:15485915
BRCA1 and FANCJ in complex inhibit G2 to M propagation (called G2 checkpoint).
FANCM:FAAP24 complex activated G2 phase checpoint (G2 to M propagation inhibition):
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair:
PMID:16713580, PMID:18543256
BER and MMR interaction and G2/M arrest inresponce to o6-meG formation:
d_re216( DNA repair  map ):
By CDC20/APC complex:
M to G1 transition
By Mitotic checkpoint complex:
Spindle checkpoint
PARP3 activated spindle checkpoint
Tankyrase activated spindle checkpoint
d_re437( DNA repair  map ):
Stalled replication forks induce PCNA mono-ubiquitylation and formation of the complex that activated TLS and arrests S-phase:
PMID:19793801, PMID:17582221, PMID:19158510, PMID:18451105

In compartment: Nucleus
  1. gRepaired_DNA*@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gDamaged_DNA*@Nucleus map map gRepaired_DNA*@Nucleus map

    2. gTC-NER_GG-NER_DNA_st6*@Nucleus map map gRepaired_DNA*@Nucleus map
    3. gShP_BER_M-glyc_st5_B-glyc_DNA_st6*@Nucleus map map gRepaired_DNA*@Nucleus map
    4. gLnP_BER_M-glyc_st6*@Nucleus map map gRepaired_DNA*@Nucleus map
    5. gMMR_DNA_st5*@Nucleus map map gRepaired_DNA*@Nucleus map
    6. gSSA_DNA_st6*@Nucleus map map gRepaired_DNA*@Nucleus map
    7. gC_NHEJ_DNA_st5*@Nucleus map map gRepaired_DNA*@Nucleus map
    8. gA_NHEJ_DNA_st6*@Nucleus map map gRepaired_DNA*@Nucleus map
    9. gHR_DNA_st7*@Nucleus map map gRepaired_DNA*@Nucleus map
    10. gTLS_DNA_st2*@Nucleus map map gRepaired_DNA*@Nucleus map
    11. gDR_DNA_st2*@Nucleus map map gRepaired_DNA*@Nucleus map

    As Catalyser:

    1. G1 phase@default map map S phase@default map

    2. S phase@default map map G2 phase@default map
    3. G2 phase@default map map M phase@default map
    4. M phase@default map map G1 phase@default map
    5. No DNA replicarion@default map map DNA replicarion@default map

    Leave a Reply