RECQL5

Protein RECQL5 map

Identifiers
RecQ protein-like 5
HUGO:RECQL5 HGNC:9950 ENTREZ:9400 UNIPROT:O94762 GENECARDS:RECQL5 KEGG:9400 ATLASONC:RECQL5ID286 WIKI:RECQL5

Maps_Modules
 DNA repair  map  / HR  map
 DNA repair  map  / BER  map

References
PMID:19772495, PMID:16697054, PMID:19847258,PMID:23161013
Activates BER
PMID:22973052

RECQL5 @default

References
d_re22( DNA repair  map ):
PMID:18398454
PMID:16449207
RECQL5 activates BER via XRCC1 and PARP1
PMID:22973052
d_re114( DNA repair  map ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833


Modifications:
In compartment: default
  1. RECQL5 @default map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

      As Catalyser:

      1. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map

      2. gHR_DNA_st5*@Nucleus map map gHR_DNA_st6*@Nucleus map
      3. POLB@default map + XRCC1|​pho@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map + WRN|​ace@default map + PNK*@default map map PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default map

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