RBX1

Protein RBX1 map

Identifiers
ring-box 1, E3 ubiquitin protein ligase
HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1
ring-box 1
“ring-box 1″

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map
 Apoptosis  map  / HIF1  map
 Apoptosis  map  / MOMP_REGULATION  map
 Apoptosis  map  / TNF_RESPONSE  map
 DNA repair  map  / S_PHASE_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / NER  map
 DNA repair  map  / FANCONI  map
 Survival  map  / HEDGEHOG  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:15459660
For NER pathway:
PMID:19809470, PMID:15703371, PMID:19847258, PMID:16697054, PMID:12648680, PMID:17884153, PMID:11900249
For Fanconi pathway:
PMID:19686080, PMID:19622404, PMID:18931676
PMID:15340381
PMID:12820959
PMID:15688063


Modifications:
In compartment: Cytoplasm
  1. RBX1@Cytoplasm map

In compartment: default

  1. RBX1@default map

Participates in complexes:
In compartment: Cytoplasm

  1. CUL3:​KEAP1:​RBX1@Cytoplasm map

  2. CUL1:​RBX1:​SKP1:​_beta_TRCP*@Cytoplasm map
  3. CUL4A:​DDB1:​RBX1:​_beta_TRCP*@Cytoplasm map
  4. CISH:​CUL2:​RBX1:​TCEB1:​TCEB2:​TCEB3@Cytoplasm map
  5. CUL2:​RACK1*:​RBX1:​TCEB1:​TCEB2:​VHL@Cytoplasm map

In compartment: Nucleus

  1. CDC53*:​RBX1:​SKP1:​SKP2@Nucleus map

  2. CDC53*:​FBW7*:​RBX1:​SKP1@Nucleus map
  3. CDT2*:​CUL4*:​DDB1*:​RBX1@Nucleus map

In compartment: default

  1. CSA*:​CUL4*:​DDB1:​RBX1@default map

  2. CUL4*:​DDB1:​DDB2:​RBX1@default map
  3. CUL1:​RBX1:​SKP1:​SKP2:​_beta_TRCP*@default map

Participates in reactions:
As Reactant or Product:

  1. _beta_TRCP*@default map + SKP1@default map + CUL1@default map + RBX1@default map + SKP2@default map map CUL1:​RBX1:​SKP1:​SKP2:​_beta_TRCP*@default map

  2. RBX1@default map + CUL4*@default map + DDB1@default map + CSA*@default map map CSA*:​CUL4*:​DDB1:​RBX1@default map
  3. DDB2@default map + RBX1@default map + CUL4*@default map + DDB1@default map map CUL4*:​DDB1:​DDB2:​RBX1@default map
  4. s_s_akt1_s822 map RICTOR|​T1135_pho@Cytoplasm map + CUL1@Cytoplasm map + RBX1@Cytoplasm map

As Catalyser:

  1. DDIT4|​pho@Cytoplasm map map DDIT4|​pho|​ubi@Cytoplasm map

  2. NFKBIA|​pho@Cytoplasm map map NFKBIA|​pho|​ubi@Cytoplasm map
  3. BCL2@Cytoplasm map map BCL2|​ubi@Cytoplasm map
  4. HIF1A|​P564_hyd@Cytoplasm map map HIF1A|​ubi|​P564_hyd@Cytoplasm map
  5. IKK_beta_*@Cytoplasm map map IKK_beta_*|​ubi@Cytoplasm map
  6. NFE2L2@Cytoplasm map map NFE2L2|​ubi@Cytoplasm map
  7. BimEL*|​S69_pho|​S98_pho|​S94_pho|​S93_pho@Cytoplasm map map degraded
  8. BimEL*@Cytoplasm map map BimEL*|​ubi@Cytoplasm map
  9. BCL2L11|​ubi@Cytoplasm map map BimEL*|​ubi@Cytoplasm map
  10. TC-NER_DNA_st1*:​Transcription machine_br_(RNAPII)*@Nucleus map map Transcription machine_br_(RNAPII)*@default map + gTC-NER_DNA_st2*@Nucleus map
  11. FANCM|​pho@default map map degraded
  12. gGG-NER_DNA_st1*@Nucleus map map gGG-NER_DNA_st2*@Nucleus map
  13. CyclinD*@default map map degraded
  14. CyclinE*@default map map degraded
  15. CDC25A@default map map degraded
  16. CDC25B@default map map degraded
  17. WEE1|​pho@default map map degraded
  18. EMI1*|​pho@default map map degraded
  19. PHLPP*|​S869_pho|​S847_pho@Cytoplasm map map PHLPP*|​S869_pho|​S847_pho|​ubi|​ubi@Cytoplasm map
  20. PDCD4|​S67_pho@Cytoplasm map map PDCD4|​S67_pho|​ubi@Cytoplasm map
  21. s_s_akt2_s384 map s_s_akt2_s399
  22. GLI3-190*|​S849_pho|​S868_pho|​S907_pho|​S873_pho|​S852_pho|​S865_pho|​S877_pho|​S903_pho|​S860_pho|​S880_pho|​S910_pho|​S1006_pho|​S980_pho:​SUFU:​ULK3@Cytoplasm map map GLI3-190*|​S849_pho|​S868_pho|​S907_pho|​S873_pho|​S852_pho|​S865_pho|​S877_pho|​S903_pho|​S860_pho|​S880_pho|​S910_pho|​S1006_pho|​S980_pho|​ubi|​ubi|​ubi|​ubi:​SUFU:​ULK3@Cytoplasm map
  23. GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho:​SUFU:​ULK3@Cytoplasm map map GLI2-185*|​S789_pho|​S805_pho|​S817_pho|​S847_pho|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi:​SUFU:​ULK3@Cytoplasm map
  24. GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytoplasm map map GLI2-185*|​S792_pho|​S808_pho|​S820_pho|​S850_pho|​S801_pho|​S813_pho|​S844_pho|​pho|​ubi|​ubi|​S385_pho|​S1011_pho:​SUFU:​ULK3@Cytoplasm map

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