RB1

Protein RB1 map

Identifiers
retinoblastoma 1
HUGO:RB1 HGNC:9884 ENTREZ:5925 UNIPROT:P06400 GENECARDS:RB1 REACTOME:62886 KEGG:5925 ATLASONC:RB1ID90 WIKI:RB1

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 DNA repair  map  / G1_CC_PHASE  map
 DNA repair  map  / S_CC_PHASE  map
 DNA repair  map  / G1_S_CHECKPOINT  map
 Cell cycle  map  / E2F1  map
 Cell cycle  map  / RB  map

References
PMID:18590585, PMID:17303408, PMID:17660363, PMID:7575488, PMID:15279786, PMID:7935440
Inhibition of E2F binding by phosphorylation at several of the 7 C-terminal sites or at one of the two serines 807 and 811.
PMID:9315635

RB1@Nucleus

References
a_re684( Apoptosis  map ):
hierarchical:post-MOMP
reactionType:casp.cleavage
PMID:9092486
a_re1125:( Apoptosis  map ) cf. Rb pathway

RB1|​pho|​pho|​pho@Nucleus

References
c_re291:( Cell cycle  map ) PMID:8380224; PMID:9315635; PMID:10773440
c_re35( Cell cycle  map ):
PMID:8380224
PMID:9315635
PMID:10773440


Modifications:
In compartment: Nucleus
  1. RB1@Nucleus map

  2. RB1|​pho|​pho|​pho@Nucleus map

In compartment: default

  1. RB1@default map

  2. RB1|​pho@default map

Participates in complexes:
In compartment: Nucleus

  1. DP1*:​E2F1:​RB1@Nucleus map

  2. DP1*:​E2F1:​RB1|​pho|​pho|​pho@Nucleus map
  3. BAF250*:​DP1*:​E2F1:​RB1@Nucleus map
  4. BAF250*:​DP1*:​E2F1:​RB1|​pho@Nucleus map
  5. BAF250*:​DP1*:​E2F1:​RB1|​pho|​pho@Nucleus map
  6. BAF250*:​DP1*:​E2F1:​RB1:​SUV39H1@Nucleus map
  7. BAF250*:​DP1*:​E2F1:​HP1gamma*:​RB1:​SUV39H1@Nucleus map

In compartment: default

  1. E2F1:​RB1@default map

  2. E2F1:​RB1|​pho@default map
  3. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​E2F1:​RB1@default map
  4. CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho:​RB1@default map

Participates in reactions:
As Reactant or Product:

  1. RB1@Nucleus map map cleaved_RB1*@Nucleus map

  2. SUV39H1@Nucleus map + BAF250*:​DP1*:​E2F1:​RB1@Nucleus map map BAF250*:​DP1*:​E2F1:​RB1:​SUV39H1@Nucleus map
  3. HDAC1@Nucleus map + DP1*:​E2F1:​RB1@Nucleus map + BAF250*@Nucleus map map BAF250*:​DP1*:​E2F1:​RB1@Nucleus map
  4. HP1gamma*@Nucleus map + BAF250*:​DP1*:​E2F1:​RB1:​SUV39H1@Nucleus map map BAF250*:​DP1*:​E2F1:​HP1gamma*:​RB1:​SUV39H1@Nucleus map
  5. BAF250*:​DP1*:​E2F1:​RB1@Nucleus map map BAF250*:​DP1*:​E2F1:​RB1|​pho@Nucleus map
  6. BAF250*:​DP1*:​E2F1:​HP1gamma*:​RB1:​SUV39H1@Nucleus map map BAF250*:​DP1*:​E2F1:​RB1@Nucleus map + HP1gamma*:​SUV39H1@Nucleus map
  7. DP1*:​E2F1:​RB1|​pho|​pho|​pho@Nucleus map map RB1|​pho|​pho|​pho@Nucleus map + DP1*:​E2F1@Nucleus map
  8. BAF250*:​DP1*:​E2F1:​RB1|​pho@Nucleus map map HDAC1@Nucleus map + BAF250*:​DP1*:​E2F1:​RB1|​pho|​pho@Nucleus map
  9. BAF250*:​DP1*:​E2F1:​RB1|​pho|​pho@Nucleus map map DP1*:​E2F1:​RB1|​pho|​pho|​pho@Nucleus map + BAF250*|​pho@Nucleus map
  10. RB1|​pho|​pho|​pho@Nucleus map map RB1@Nucleus map
  11. DP1*:​E2F1@Nucleus map + RB1@Nucleus map map DP1*:​E2F1:​RB1@Nucleus map
  12. E2F1@default map + RB1@default map map E2F1:​RB1@default map
  13. E2F1:​RB1@default map map E2F1:​RB1|​pho@default map
  14. E2F1:​RB1|​pho@default map map RB1|​pho@default map + E2F1@default map
  15. E2F1:​RB1@default map map E2F1@default map + RB1@default map
  16. RB1|​pho@default map map degraded
  17. E2F1:​RB1|​pho@default map map E2F1:​RB1@default map
  18. CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho@default map + RB1@default map map CTBP*|​S181_pho|​T179_pho|​S185_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho:​RB1@default map
  19. E2F1:​RB1@default map + BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho|​active@default map map BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​E2F1:​RB1@default map

As Catalyser:

  1. E2F1@Nucleus map map E2F1@Nucleus map

  2. G1 phase@default map map S phase@default map

29 thoughts on “RB1

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