RASGRP1

Protein RASGRP1 map

Identifiers
RAS guanyl releasing protein 1 (calcium and DAG-regulated)
HUGO:RASGRP1 HGNC:9878 ENTREZ:10125 UNIPROT:O95267 GENECARDS:RASGRP1 REACTOME:231214 KEGG:10125 ATLASONC:GC_RASGRP1 WIKI:RASGRP1

Maps_Modules
 Survival  map  / MAPK  map

References
RasGRP1 specifically activates H-Ras in the Golgi. It is localised in the cytosol in quiescent cells. After PMA stimulus at first it moves to the PM and then shifts towards other subcellular compartments like the Golgi apparatus.
RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+ in a manner analogous to members of the PKC family.
PMID:12782630 PMID:17496910
Activation of PKC: http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html

RASGRP1@Cytoplasm

References
s_mpk1_re46( Survival  map ):
RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+ in a manner analogous to members of the PKC family.
PMID:17496910
DAG remains in the inner layer of the plasma membrane. It recruits Protein Kinase C (PKC) — a calcium-dependent kinase that phosphorylates many other proteins that bring about the changes in the cell.
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html


Modifications:
In compartment: Cytoplasm
  1. RASGRP1@Cytoplasm map

Participates in complexes:
In compartment: Golgi Apparatus

  1. Ca2+:​DAG:​RASGRP1@Golgi Apparatus map

  2. Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus map
  3. Ca2+:​DAG:​RAF1|​pho:​RAS*|​pho:​RASGRP1@Golgi Apparatus map

In compartment: Plasma Membrane

  1. DAG:​RASGRP1@Plasma Membrane map

  2. Ca2+:​DAG:​RASGRP1@Plasma Membrane map

Participates in reactions:
As Reactant or Product:

  1. RAS*@Plasma Membrane map + Ca2+:​DAG:​RASGRP1@Golgi Apparatus map map Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus map

  2. DAG@Plasma Membrane map + RASGRP1@Cytoplasm map map DAG:​RASGRP1@Plasma Membrane map
  3. DAG:​RASGRP1@Plasma Membrane map + Ca2+@Cytoplasm map map Ca2+:​DAG:​RASGRP1@Plasma Membrane map
  4. Ca2+:​DAG:​RASGRP1@Plasma Membrane map map Ca2+:​DAG:​RASGRP1@Golgi Apparatus map
  5. RAF1@Cytoplasm map + Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus map map Ca2+:​DAG:​RAF1|​pho:​RAS*|​pho:​RASGRP1@Golgi Apparatus map

As Catalyser:

  1. ERK*:​MEK*:​SEF*@Golgi Apparatus map map ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map

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