RAS*

Protein RAS* map

Identifiers
RAS p21 protein activator (GTPase activating protein) 1
HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1
RAS p21 protein activator 2
HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2
RAS p21 protein activator 3
HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3
RAS p21 protein activator 4
HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4
v-Ha-ras Harvey rat sarcoma viral oncogene homolog
HRAS1
HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
KRAS2 “v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog”
HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS
neuroblastoma RAS viral (v-ras) oncogene homolog
HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS

Maps_Modules
 Survival  map  / HEDGEHOG  map
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:21102635
RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output.
RasGRP1 activates Golgi-associated Ras on this compartment.
K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus.
Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle.
H-Ras but not K-Ras signalling was dependent on endocytosis.
PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955

RAS*@Cytoplasm

References
s_shh1_re98:( Survival  map ) PMID:18829525
s_akt1_re6( Survival  map ):
PMID:15534002
PMID:9779982
PMID:14585353
s_akt1_re11( Survival  map ):
PMID:15584861
PMID:10648629

RAS*@Plasma Membrane

References
s_mpk1_re67( Survival  map ):
Calcium activates the Ras GAP CAPRI (RASA4) that translocates to the PM and downregulates any Ras that is activated on this compartment by the exchange factor SOS.
PMID:16488589
s_mpk1_re9( Survival  map ):
Sos mediates Ras activation. Interaction of Sos with Ras induces the formation of RasGTP from RasGDP.
Spry is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2.
PMID:17496910 PMID:15173823
s_mpk1_re285( Survival  map ):
RasGRP1 activates Golgi-associated Ras on this compartment.
s_s_mpk1_re285( Survival  map ):


Modifications:
In compartment: Cytoplasm
  1. RAS*@Cytoplasm map

  2. RAS*@Cytoplasm map

In compartment: Plasma Membrane

  1. RAS*@Plasma Membrane map

Participates in complexes:
In compartment: Cytoplasm

  1. MAP3K1|​pho:​RAS*|​pho:​RTK*@Cytoplasm map

  2. MAP3K2_3*|​pho:​RAS*|​pho:​RTK*@Cytoplasm map

In compartment: Endosome

  1. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map

In compartment: Golgi Apparatus

  1. Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus map

  2. Ca2+:​DAG:​RAF1|​pho:​RAS*|​pho:​RASGRP1@Golgi Apparatus map

In compartment: Late Endosomes

  1. GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map

  2. GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map
  3. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map

In compartment: Lipid Raft

  1. RAS*:​p110*:​p85*@Lipid Raft map

  2. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map

In compartment: Plasma Membrane

  1. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map

  2. BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  3. GRB2:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  4. BRAF|​pho:​GRB2:​KSR1-NTER*:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  5. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  6. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map

Participates in reactions:
As Reactant or Product:

  1. p110*:​p85*@Cytoplasm map + s_s_akt1_s53 + PI3,4,5-P3@Lipid Raft map + RTK*@Cytoplasm map + GF@default map + RAS*@Cytoplasm map + GAB1|​Y977_pho|​Y989_pho@Cytoplasm map map GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map

  2. GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map map Ubiquitination@Cytoplasm map
  3. GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map map GAB1:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Endosome map
  4. RAS activation@Cytoplasm map map RAS*@Cytoplasm map
  5. p110*:​p85*@Cytoplasm map + RAS*@Cytoplasm map map RAS*:​p110*:​p85*@Lipid Raft map
  6. RAF1@Cytoplasm map + GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map GRB2:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  7. GRB2:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + RAF1|​pho@Mitochondria map
  8. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + BRAF@Cytoplasm map map BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  9. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + MAP3K1@Cytoplasm map map MAP3K1|​pho:​RAS*|​pho:​RTK*@Cytoplasm map
  10. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + MAP3K2_3*@Cytoplasm map map MAP3K2_3*|​pho:​RAS*|​pho:​RTK*@Cytoplasm map
  11. BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + KSR1:​MEK*@Cytoplasm map map BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  12. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + ERK*@Cytoplasm map map BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  13. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + LAMTOR2:​MEK*:​MP1*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map
  14. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*@Cytoplasm map + RAF1@Cytoplasm map
  15. RAF1@Cytoplasm map + GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map
  16. ERK*@Cytoplasm map + GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map
  17. RAS*@Plasma Membrane map + Ca2+:​DAG:​RASGRP1@Golgi Apparatus map map Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus map
  18. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map KSR1:​MEK*@Cytoplasm map + BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + ERK*|​pho|​pho@Cytoplasm map
  19. BRAF|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map BRAF|​pho:​GRB2:​KSR1-NTER*:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map + KSR1-CTER*:​MEK*@Cytoplasm map
  20. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*|​pho|​pho@Cytoplasm map
  21. RAF1@Cytoplasm map + Ca2+:​DAG:​RAS*|​pho:​RASGRP1@Golgi Apparatus map map Ca2+:​DAG:​RAF1|​pho:​RAS*|​pho:​RASGRP1@Golgi Apparatus map
  22. GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map RAS*@Plasma Membrane map + GRB2:​RTK*:​SOS*@Plasma Membrane map
  23. BRAF|​pho:​ERK*|​pho|​pho:​GRB2:​KSR1:​MEK*|​pho|​pho:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map map ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map + BRAF|​pho:​GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  24. RAS*@Plasma Membrane map + GRB2:​RTK*:​SOS*@Plasma Membrane map map GRB2:​RAS*|​pho:​RTK*:​SOS*@Plasma Membrane map
  25. RAS activation@Cytoplasm map map RAS*@Cytoplasm map

As Catalyser:

  1. PtdIns(4,5)-P2@Lipid Raft map map PI3,4,5-P3@Lipid Raft map

  2. MAP2K4@Cytoplasm map map MAP2K4|​pho|​pho@Cytoplasm map
  3. MAP2K7@Cytoplasm map map MAP2K7|​pho|​pho@Cytoplasm map
  4. MAP2K6@Cytoplasm map map MAP2K6|​pho|​pho@Cytoplasm map
  5. MEK*@Cytoplasm map map MEK*|​pho|​pho@Cytoplasm map
  6. IMP*:​KSR1:​MEK*@Cytoplasm map map IMP*@Cytoplasm map + KSR1:​MEK*@Cytoplasm map
  7. ERK*:​MEK*:​SEF*@Golgi Apparatus map map ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map
  8. SUFU@Cytoplasm map + SIL*@Cytoplasm map map SIL*:​SUFU@Cytoplasm map

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