RAF1:YWHAB

Complex RAF1:YWHAB map


Complex composition:

  1. YWHAB map
  2. RAF1 map




RAF1|​S259_pho|​S621_pho|​S_pho|​closed:​YWHAB@Cytoplasm

Identifiers
NAME:RAF1:YWHAB

Maps_Modules
 EMT  map  / EMT_REGULATORS  map

References
PMID:9069260
Inactive RAF1 is associated in the cytoplasm with YWHAB.
YWHAB binds to RAF1 via the Ser259 phosphorylation site.
This interaction stabilises the inactive conformation of RAF1, in which the RAS-binding Cysteine-rich doomain (CRD) is obscured.
RAF1 contains an additional RAS-binding domain (RBD).
e_re385( EMT  map ):
Activated HRAS (GTP bound forn) is associated with the plasma membrane.
Inactive RAF1 is associated in the cytoplasm with YWHAB via S259 phosphorylation site and also binding site.
RAF1 has a RAS-binding Cysteine-rich domain (CRD) and an additional RAS-binding domain (RBD).
RAF1 binds activated HRAS via the RBD. This binding displaces YWHAB from Ser259 and unmasks the CRD.

Confidence
REF=0 FUNC=5


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. RAF1|​S259_pho|​S621_pho|​S_pho|​closed:​YWHAB@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm map + YWHAB@Cytoplasm map map RAF1|​S259_pho|​S621_pho|​S_pho|​closed:​YWHAB@Cytoplasm map

  2. RAF1|​S259_pho|​S621_pho|​S_pho|​closed:​YWHAB@Cytoplasm map + GTP:​HRAS@Cytoplasm map map GTP:​HRAS:​RAF1|​S259_pho|​S621_pho|​S_pho|​closed@Cytoplasm map + YWHAB@Cytoplasm map

As Catalyser:

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