RAC1

Protein RAC1 map

Identifiers
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1
Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / TIGHT_JUNCTIONS  map
 EMT  map  / CYTOSKELETON_POLARITY  map
 Apoptosis  map  / TNF_RESPONSE  map
 Survival  map  / HEDGEHOG  map
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:18000759
PMID:19151919
Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2).
PMID:11274345

RAC1@Plasma Membrane

References
s_mpk1_re150( Survival  map ):
Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2).
PMID:11274345


Modifications:
In compartment: Cytoplasm
  1. RAC1@Cytoplasm map

In compartment: Plasma Membrane

  1. RAC1@Plasma Membrane map

Participates in complexes:
In compartment: Cytoplasm

  1. GDP:​RAC1@Cytoplasm map

  2. GTP:​RAC1@Cytoplasm map
  3. NCK1:​RAC1@Cytoplasm map
  4. MAP3K10_11*|​pho:​RAC1|​pho:​RTK*@Cytoplasm map

In compartment: Endosome

  1. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map

In compartment: Lipid Raft

  1. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map

  2. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft map
  3. DEPTOR:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map

In compartment: Membrane Lysosome

  1. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map

  2. MLST8:​MTOR|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  3. MLST8:​MTOR|​S2448_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  4. MLST8:​MTOR|​S1261_pho|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  5. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  6. DEPTOR:​MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  7. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome map
  8. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  9. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map

In compartment: Plasma Membrane

  1. GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane map

Participates in reactions:
As Reactant or Product:

  1. RAC1@Cytoplasm map map RAC1_2*@Cytoplasm map

  2. rRAC1@Nucleus map map RAC1@Cytoplasm map
  3. RAC1@Cytoplasm map map GTP:​RAC1@Cytoplasm map
  4. GDP:​RAC1@Cytoplasm map map GTP:​RAC1@Cytoplasm map
  5. GTP:​RAC1@Cytoplasm map map GDP:​RAC1@Cytoplasm map
  6. GTP:​RAC1@Cytoplasm map map ARHGEF14*@Cytoplasm map
  7. GTP:​RAC1@Cytoplasm map map NCKAP1@Cytoplasm map
  8. GTP:​RAC1@Cytoplasm map map CYFIP2@Cytoplasm map
  9. GTP:​RAC1@Cytoplasm map + NCK1@Cytoplasm map map NCK1:​RAC1@Cytoplasm map
  10. GTP:​RAC1@Cytoplasm map map Membrane spreading@Cytoplasm map
  11. PRAS40*@Cytoplasm map + MLST8@Cytoplasm map + RPTOR@Cytoplasm map + MTOR|​S2448_pho@Cytoplasm map map MLST8:​MTOR|​S2448_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  12. PRAS40*@Cytoplasm map + MLST8@Cytoplasm map + RPTOR@Cytoplasm map + MTOR@Cytoplasm map + RAC1@Cytoplasm map map s_s_akt1_s873
  13. DEPTOR@Cytoplasm map + MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map map DEPTOR:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map
  14. s_s_akt1_s864 map MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map
  15. s_s_akt1_s873 map MLST8:​MTOR|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  16. MLST8:​MTOR|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  17. MLST8:​MTOR|​S1261_pho|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  18. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome map
  19. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  20. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  21. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map + PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map
  22. DEPTOR@Cytoplasm map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map + DEPTOR:​MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  23. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map map (MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm map
  24. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map map MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft map
  25. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft map + 14-3-3*@Lipid Raft map map 14-3-3*:​MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RICTOR|​T1135_pho@Lipid Raft map
  26. GRB2:​RTK*:​SOS*@Plasma Membrane map + RAC1@Plasma Membrane map map GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane map
  27. GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane map map RAC1@Plasma Membrane map + GRB2:​RTK*:​SOS*@Plasma Membrane map
  28. GRB2:​RAC1|​pho:​RTK*:​SOS*@Plasma Membrane map + MAP3K10_11*@Cytoplasm map map MAP3K10_11*|​pho:​RAC1|​pho:​RTK*@Cytoplasm map
  29. GDP:​RAC1@Cytoplasm map + GTP@Cytoplasm map map GTP:​RAC1@Cytoplasm map + GDP@Cytoplasm map
  30. GTP:​RAC1@Cytoplasm map map EMT@Cytoplasm map
  31. RAC1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  32. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RAC1:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map map RAC1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​FZD*:​PAR6*:​PRR*:​RACK1*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​WNT*:​_beta_-Arrestin2*@Endosome map
  33. RAC1@Cytoplasm map + POSH*@Cytoplasm map map s_s_wnc1_s945
  34. GTP:​RAC1@Cytoplasm map + PLC-_beta_*@Cytoplasm map map s_s_wnc1_s288

As Catalyser:

  1. LEF1_TCF3_4*@Nucleus map + _beta_-Catenin*@Cytoplasm map map LEF1_TCF3_4*:​_beta_-Catenin*@Nucleus map

  2. PAK*@Cytoplasm map map PAK*|​pho|​active@Cytoplasm map
  3. MAP3K7_10_11*@Cytoplasm map map MAP3K7_10_11*@Cytoplasm map
  4. PAR6*@Cytoplasm map map PAR6*@Cytoplasm map
  5. ARFIP2@Cytoplasm map map ARFIP2@Cytoplasm map
  6. PIP5K1*@Cytoplasm map map PIP5K1*@Cytoplasm map
  7. BAIAP2@Cytoplasm map map BAIAP2@Cytoplasm map
  8. PAK1@Cytoplasm map + NISCH@Nucleus map map NISCH:​PAK1@Cytoplasm map
  9. ATG13:​FIP200*:​ULK*@Cytoplasm map map ATG13|​pho:​FIP200*:​ULK*|​pho@Cytoplasm map
  10. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map map AKT1|​T308_pho|​T450_pho|​S473_pho:​PI3,4,5-P3@Lipid Raft map
  11. AKT1|​T450_emp|​S473_emp|​S129_emp@Cytoplasm map map AKT1|​T450_pho|​S473_emp|​active@Cytoplasm map
  12. MLST8:​MTOR|​S1261_pho|​S2448_emp:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map
  13. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*:​RAC1:​RPTOR@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S863_pho|​S877_pho@Membrane Lysosome map
  14. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_emp|​T246_emp:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map
  15. MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map map MLST8:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RAC1:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho@Membrane Lysosome map + PRAS40*|​S183_pho|​T246_pho|​S212_pho|​S221_pho@Membrane Lysosome map
  16. SGK1@Cytoplasm map map SGK1|​S442_pho@Cytoplasm map
  17. MAP2K4@Cytoplasm map map MAP2K4|​pho|​pho@Cytoplasm map
  18. MAP2K7@Cytoplasm map map MAP2K7|​pho|​pho@Cytoplasm map
  19. MEK*@Cytoplasm map map MEK*|​pho|​pho@Cytoplasm map
  20. ATP6V0C_D*@Cytoplasm map map ATP6V0C_D*@Endosome map
  21. ATP6V0C_D*@Cytoplasm map map ATP6V0C_D*@Endosome map

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