PTEN

Protein PTEN map

Identifiers
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN
HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN
phosphatase and tensin homolog
phosphatase and tensin homologue
BZS, MHAM

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:12040186
PMID:16288286
PMID:17218262

PTEN|​pho|​active@Cytoplasm

References
e_re718( EMT  map ):
PMID:20008297
ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.
PMID:22074495

PTEN@Cytoplasm

References
e_re718( EMT  map ):
PMID:20008297
ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability.
PMID:22074495

PTEN|​S370_pho@Cytoplasm

References
s_akt1_re81( Survival  map ):
PMID:17444818
ANNOTATION:PTEN is destabilized by phosphorylation on T366 followed by phosphorylation on S370 by GSK3beta.

PTEN|​K289_ubi|​K13_ubi@Cytoplasm

References
s_akt1_re16( Survival  map ):
PMID:17218261
PMID:17218260

PTEN|​K13_ubi@Cytoplasm

References
s_akt1_re14( Survival  map ):
PMID:17218261
PMID:17218260

PTEN|​K13_ubi@Nucleus

References
s_akt1_re15( Survival  map ):
PMID:17218261
PMID:17218260

PTEN|​K289_ubi@Cytoplasm

References
s_akt1_re25( Survival  map ):
PMID:17218261
PMID:17218260

PTEN|​K289_ubi@Nucleus

References
s_akt1_re26( Survival  map ):
PMID:17218261
PMID:17218260

PTEN|​S370_pho|​T366_pho@Cytoplasm

References
s_akt1_re82( Survival  map ):
PMID:17444818
ANNOTATION:PTEN is destabilized by phosphorylation on T366 followed by phosphorylation on S370 by GSK3beta.
s_akt1_re12( Survival  map ):
PMID:19652529
PMID:19597351

PTEN|​S370_pho|​S380_pho|​T382_pho|​T383_pho|​S385_pho@Cytoplasm

References
s_akt1_re147( Survival  map ):
PMID:11707428
phospho- rylation of the PTEN tail negatively regulates PTEN activity
PMID:11035045
phosphorylation of PTEN by CK2 is important for PTEN protein stability to proteasome-mediated degradation

PTEN|​ubi@Nucleus

References
s_akt2_re14:( Survival  map ) PMID:18716620
s_akt2_re18( Survival  map ):
PMID:17218262
PMID:17218252

PTEN|​emp@Nucleus

References
s_akt2_re14:( Survival  map ) PMID:18716620


Modifications:
In compartment: Cytoplasm
  1. PTEN@Cytoplasm map

  2. PTEN|​emp@Cytoplasm map
  3. PTEN|​ubi@Cytoplasm map
  4. PTEN|​ubi@Cytoplasm map
  5. PTEN|​K13_ubi@Cytoplasm map
  6. PTEN|​K289_ubi@Cytoplasm map
  7. PTEN|​S370_pho@Cytoplasm map
  8. PTEN|​pho|​active@Cytoplasm map
  9. PTEN|​K289_ubi|​K13_ubi@Cytoplasm map
  10. PTEN|​S370_pho|​T366_pho@Cytoplasm map
  11. PTEN|​S370_pho|​S380_pho|​T382_pho|​T383_pho|​S385_pho@Cytoplasm map

In compartment: Nucleus

  1. PTEN@Nucleus map

  2. PTEN|​emp@Nucleus map
  3. PTEN|​ubi@Nucleus map
  4. PTEN|​ubi@Nucleus map
  5. PTEN|​K13_ubi@Nucleus map
  6. PTEN|​K289_ubi@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. PTEN|​pho|​pho|​pho|​pho:​_beta_-Arrestin*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. rPTEN@Nucleus map map PTEN@Cytoplasm map

  2. PTEN@Cytoplasm map map PTEN|​pho|​active@Cytoplasm map
  3. rPTEN@Nucleus map map PTEN@Cytoplasm map
  4. PTEN@Cytoplasm map map PTEN@Cytoplasm map
  5. PTEN@Cytoplasm map map PTEN|​K13_ubi@Cytoplasm map
  6. PTEN@Cytoplasm map map PTEN|​S370_pho|​S380_pho|​T382_pho|​T383_pho|​S385_pho@Cytoplasm map
  7. PTEN|​K13_ubi@Cytoplasm map map PTEN|​K13_ubi@Nucleus map
  8. PTEN|​K13_ubi@Nucleus map map PTEN@Nucleus map
  9. PTEN|​K289_ubi@Nucleus map map PTEN@Nucleus map
  10. PTEN@Nucleus map map PTEN@Cytoplasm map
  11. PTEN@Cytoplasm map map PTEN|​K289_ubi|​K13_ubi@Cytoplasm map
  12. PTEN@Cytoplasm map map PTEN|​K289_ubi@Cytoplasm map
  13. PTEN|​K289_ubi@Cytoplasm map map PTEN|​K289_ubi@Nucleus map
  14. PTEN@Cytoplasm map map PTEN|​S370_pho@Cytoplasm map
  15. PTEN|​S370_pho@Cytoplasm map map PTEN|​S370_pho|​T366_pho@Cytoplasm map
  16. PTEN|​ubi@Nucleus map map PTEN|​emp@Nucleus map
  17. PTEN|​ubi@Nucleus map map PTEN|​emp@Nucleus map
  18. PTEN|​emp@Nucleus map map PTEN|​emp@Cytoplasm map
  19. PTEN|​ubi@Nucleus map map Chromosome integrity and DSB repair@Nucleus map
  20. PTEN|​ubi@Nucleus map map Chromosome integrity and DSB repair@Nucleus map
  21. PTEN|​ubi@Cytoplasm map map PTEN|​ubi@Nucleus map
  22. PTEN|​ubi@Cytoplasm map map PTEN|​ubi@Nucleus map
  23. PTEN|​pho|​pho|​pho|​pho:​_beta_-Arrestin*@Cytoplasm map map PI3K AKT MTOR pathway@Cytoplasm map
  24. _beta_-Arrestin*@Cytoplasm map + PTEN@Cytoplasm map map PTEN|​pho|​pho|​pho|​pho:​_beta_-Arrestin*@Cytoplasm map
  25. PTEN|​pho|​pho|​pho|​pho:​_beta_-Arrestin*@Cytoplasm map map Cell migration@Nucleus map

As Catalyser:

  1. PI(3)P@Cytoplasm map map PI@Cytoplasm map

  2. AKT1@Cytoplasm map map AKT1@Cytoplasm map
  3. p110*:​p85*@Cytoplasm map + s_s_akt1_s53 + PI3,4,5-P3@Lipid Raft map + RTK*@Cytoplasm map + GF@default map + RAS*@Cytoplasm map + GAB1|​Y977_pho|​Y989_pho@Cytoplasm map map GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map
  4. PTEN@Cytoplasm map map PTEN@Cytoplasm map
  5. PI3,4,5-P3@Lipid Raft map map PtdIns(4,5)-P2@Lipid Raft map
  6. gRAD51@Nucleus map map rRAD51@Nucleus map

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