PTCH*

Protein PTCH* map

Identifiers
Patched 1
HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1
Patched 2
HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2

Maps_Modules
 Survival  map  / HEDGEHOG  map

References
PMID:10021362
PMID:17641202

PTCH*@Primary Cilium

References
s_shh1_re85:( Survival  map ) PMID:11331587
s_shh1_re49( Survival  map ):
PMID:20016067
the PTC receptor itself does not trigger the activation of PKA but the withdrawal of the SHH ligand does
PMID:16537363

PTCH*@Cytoplasm

Maps_Modules
 Survival  map  / HEDGEHOG  map

References
s_shh3_re6:( Survival  map ) PMID:17430994


Modifications:
In compartment: Cytoplasm
  1. PTCH*@Cytoplasm map

In compartment: Primary Cilium

  1. PTCH*@Primary Cilium map

Participates in complexes:
In compartment: Cytoplasm

  1. Ligand:​PTCH*@Cytoplasm map

  2. HH Ligand:​PTCH*@Cytoplasm map
  3. G_alpha__sub_i_endsub_*:​Ligand:​PTCH*:​SMO@Cytoplasm map
  4. G_alpha__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm map
  5. Caspase9*|​hm2:​DRAL*:​PTCH*:​TUCAN*@Cytoplasm map
  6. G_alpha__sub_i_endsub_*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm map

In compartment: Primary Cilium

  1. CyclinB*:​PTCH*@Primary Cilium map

  2. HH Ligand:​PTCH*@Primary Cilium map

Participates in reactions:
As Reactant or Product:

  1. CDO*:​HH Ligand@Primary Cilium map map HH Ligand:​PTCH*@Primary Cilium map

  2. GAS1:​HH Ligand@Primary Cilium map map HH Ligand:​PTCH*@Primary Cilium map
  3. BOC:​HH Ligand@Primary Cilium map map HH Ligand:​PTCH*@Primary Cilium map
  4. HH Ligand@default map + PTCH*@Primary Cilium map map HH Ligand:​PTCH*@Primary Cilium map
  5. HH Ligand:​PTCH*@Primary Cilium map map HH Ligand:​PTCH*@Cytoplasm map
  6. HH Ligand:​PTCH*@Cytoplasm map + G_alpha__sub_i_endsub_*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*:​SMO@Cytoplasm map + GTP@Cytoplasm map map G_alpha__sub_i_endsub_*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm map + GDP@Cytoplasm map
  7. G_alpha__sub_i_endsub_*:​G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm map map HH Ligand:​PTCH*@Cytoplasm map + SMO@Cytoplasm map + s_s_shh1_s589 + G_beta__sub_i_endsub_*:​G_gamma__sub_i_endsub_*@Cytoplasm map
  8. PTCH*@Primary Cilium map + CyclinB*@Primary Cilium map map CyclinB*:​PTCH*@Primary Cilium map
  9. CyclinB*:​PTCH*@Primary Cilium map map CyclinB*@Primary Cilium map + PTCH*@Primary Cilium map
  10. Ligand@default map + PTCH*@Cytoplasm map map Ligand:​PTCH*@Cytoplasm map
  11. G_alpha__sub_i_endsub_*:​SMO@Cytoplasm map + Ligand:​PTCH*@Cytoplasm map map G_alpha__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm map
  12. PTCH*@Cytoplasm map + DRAL*@Cytoplasm map + TUCAN*@Cytoplasm map + Caspase9*@Cytoplasm map map Caspase9*|​hm2:​DRAL*:​PTCH*:​TUCAN*@Cytoplasm map
  13. G_alpha__sub_i_endsub_*:​HH Ligand:​PTCH*:​SMO@Cytoplasm map + GTP@Cytoplasm map map G_alpha__sub_i_endsub_*:​Ligand:​PTCH*:​SMO@Cytoplasm map + GDP@Cytoplasm map
  14. G_alpha__sub_i_endsub_*:​Ligand:​PTCH*:​SMO@Cytoplasm map map PTCH*@Cytoplasm map + s_s_shh3_s60 + G_beta_*:​G_gamma_*@Cytoplasm map + SMO@Cytoplasm map

As Catalyser:

  1. AKAP*:​PKA*@Primary Cilium map map PKA*@Primary Cilium map + AKAP*@Primary Cilium map

  2. CyclinB*:​PTCH*@Primary Cilium map map CyclinB*@Primary Cilium map + PTCH*@Primary Cilium map

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