PRKCZ

Protein PRKCZ map

Identifiers
protein kinase C, zeta
HUGO:PRKCZ HGNC:9412 ENTREZ:5590 UNIPROT:Q05513 GENECARDS:PRKCZ REACTOME:58219 KEGG:5590 ATLASONC:GC_PRKCZ WIKI:PRKCZ

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / MOMP_REGULATION  map

PRKCZ@Cytoplasm

References
e_re772( EMT  map ):
RAC1 binds directly to PARD6 that activates PRKCZ.
This leads to establishment of the cell polarity and promotes cellular transformation.
PMID:10873802
PARD6 links Rac1 and Cdc42 to PKCzeta signaling and cell transformation.
PMID:10934475
PARD6 binds to Cdc42; Rac1; PARD3; PRKC isoforms.
In vitro, PARD3 acts as a substrate and an inhibitor of PRKC.
PARD3 and PARD6 have a scaffolding function, coordinating the activities of several signalling proteins that are implicated in mammalian cell polarity.
PMID:10954424
PARD6 is a binding partner for the Rho GTPases Cdc42 and Rac1


Modifications:
In compartment: Cytoplasm
  1. PRKCZ@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. PKC*@Cytoplasm map map PRKCZ@Cytoplasm map

    2. PRKCZ@Cytoplasm map map PRKCZ@Cytoplasm map
    3. PRKCZ@Cytoplasm map map Establishment of cell polarity@Nucleus map

    As Catalyser:

    1. BAX@Cytoplasm map map BAX|​S184_pho@Cytoplasm map

    2. Caspase9*|​S196_unk|​T125_unk|​Y153_unk@Cytoplasm map map Caspase9*|​S196_unk|​T125_unk|​S144_pho|​Y153_unk@Cytoplasm map

    Leave a Reply