PRKCE

Protein PRKCE map

Identifiers
protein kinase C, epsilon
HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / GAP_JUNCTIONS  map

References
GJA1 is so-called Connexin 43
PMID:16492141
Binding partners proteins of Connexin 43 (GJA1):
-Kinases: v-Src, c-Src, PKC, PKA, MAPK, Casein kinase 1, Cdc2 kinase
-TIGHT_JUNCTIONS scaffold proteins: ZO1, ZO2, caveolin 1
-Cytoskeleton: b-catenin, a-tubulin, b-tubulin
-Others: Drebrin, NOV, CIP85
PMID:10871288
Interaction between Connexin 43 (GJA1) and PKC (alpha, betat and gamma subunits)
The 3 subunits phosphorylate GJA1 at Ser368 and reduce Gap junctions activity.
PMID:10679481
Fibroblast growth factor-2 (FGF-2)decreases cardiomyocyte GJ permeability by stimulating phosphorylation of connexin-43
FGF-2 activates receptors linked to PKC and MAPK
In immunoprecipitation experiments using specific anti-Cx43 antibodies, PKCE but not PKCA coprecipitated with Cx43.
FGF-2 increased levels of coprecipitated PKCE, suggesting increased association between PKCE and Cx43 on stimulation.
To conclude, PKC mediates the FGF-2–induced effects on cardiac GJs and that PKC likely interacts with and phosphorylates cardiac Cx43 at sites of intercellular contact


Modifications:
In compartment: Cytoplasm
  1. PRKCE@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. rPRKCE@Nucleus map map PRKCE@Cytoplasm map

    2. PKC*@Cytoplasm map map PRKCE@Cytoplasm map

    As Catalyser:

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