PRKCA

Protein PRKCA map

Identifiers
protein kinase C, alpha
HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / GAP_JUNCTIONS  map
 Apoptosis  map  / MOMP_REGULATION  map
 Survival  map  / PI3K_AKT_MTOR  map

References
GJA1 is so-called Connexin 43
PMID:16492141
Binding partners proteins of Connexin 43 (GJA1):
-Kinases: v-Src, c-Src, PKC, PKA, MAPK, Casein kinase 1, Cdc2 kinase
-TIGHT_JUNCTIONS scaffold proteins: ZO1, ZO2, caveolin 1
-Cytoskeleton: b-catenin, a-tubulin, b-tubulin
-Others: Drebrin, NOV, CIP85
PMID:10871288
Interaction between Connexin 43 (GJA1) and PKC (alpha, betat and gamma subunits)
The 3 subunits phosphorylate GJA1 at Ser368 and reduce Gap junctions activity.
PMID:10679481
Fibroblast growth factor-2 (FGF-2)decreases cardiomyocyte GJ permeability by stimulating phosphorylation of connexin-43
FGF-2 activates receptors linked to PKC and MAPK
In immunoprecipitation experiments using specific anti-Cx43 antibodies, PKCE but not PKCA coprecipitated with Cx43.
FGF-2 increased levels of coprecipitated PKCE, suggesting increased association between PKCE and Cx43 on stimulation.
To conclude, PKC mediates the FGF-2–induced effects on cardiac GJs and that PKC likely interacts with and phosphorylates cardiac Cx43 at sites of intercellular contact
PMID:20027184

PRKCA@Lipid Raft

References
s_akt1_re175:( Survival  map ) PMID:18851840
s_akt1_re174( Survival  map ):
PMID:20027184
PMID:21474067


Modifications:
In compartment: Cytoplasm
  1. PRKCA@Cytoplasm map

In compartment: Lipid Raft

  1. PRKCA@Lipid Raft map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. PKC*@Cytoplasm map map PRKCA@Cytoplasm map

    2. PRKCA@Cytoplasm map map PRKCA@Lipid Raft map

    As Catalyser:

    1. BCL2@Mitochondrial outer membrane map map BCL2|​pho@Mitochondrial outer membrane map

    2. s_s_akt1_s864 map MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map

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