PRICKLE1

Protein PRICKLE1 map

Identifiers
prickle homolog 1 (Drosophila)
“prickle-like 1 (Drosophila)”
HUGO:PRICKLE1 HGNC:17019 ENTREZ:144165 UNIPROT:Q96MT3 GENECARDS:PRICKLE1 KEGG:144165 ATLASONC:GC_PRICKLE1 WIKI:PRICKLE1

Maps_Modules
 Survival  map  / WNT_NON_CANONICAL  map

References
Prickle is actually associated with membrane

PRICKLE1@Cytoplasm

References
s_wnc1_re78:( Survival  map ) PMID:22037766

PRICKLE1|​pho@Cytoplasm

References
s_wnc1_re78:( Survival  map ) PMID:22037766
s_wnc1_re85( Survival  map ):
Prickle interacts physically with Vangl
PMID:22037766
PMID:12941693
Par6 is constitutively associated with Dvl
PMID:19379695

PRICKLE1|​pho|​ubi@Cytoplasm

References
s_wnc1_re111( Survival  map ):
Rspo is required for clathrin-mediated endocytosis
PMID:21397842
It has been shown that Dvl polymers are not associated with vesicles, therefore endocytosis of the complex is likely to be after Dvl polymerisation.
PMID:16263762
s_wnc1_re90( Survival  map ):
PMID:19379695
PMID:20930545


Modifications:
In compartment: Cytoplasm
  1. PRICKLE1@Cytoplasm map

  2. PRICKLE1|​pho@Cytoplasm map
  3. PRICKLE1|​pho|​ubi@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. PRICKLE1|​pho:​VANGL*@Cytoplasm map

  2. CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*@Cytoplasm map
  3. CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*@Cytoplasm map
  4. CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map
  5. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map
  6. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  7. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  8. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map + RSPO3@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRR*:​ROR2:​RSPO3:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map + SMURF1@Cytoplasm map + PRICKLE1|​pho|​ubi@Cytoplasm map

  2. ROR2@Cytoplasm map + FZD*:​GDP:​G_alpha_*:​G_beta_*:​G_gamma_*@Cytoplasm map + WNT*@default map + GTP@Cytoplasm map + CK1_epsilon_*@Cytoplasm map + CTHRC1@Cytoplasm map + SYN4*@Cytoplasm map + PRICKLE1|​pho:​VANGL*@Cytoplasm map + PRR*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*@Cytoplasm map + GDP@Cytoplasm map
  3. CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*@Cytoplasm map map s_s_wnc1_s259 + CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*@Cytoplasm map + G_beta_*:​G_gamma_*@Cytoplasm map
  4. CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*@Cytoplasm map + DVL*|​pho|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  5. PRICKLE1@Cytoplasm map map PRICKLE1|​pho@Cytoplasm map
  6. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map + DVL*|​pho|​emp|​emp|​ubi@Cytoplasm map
  7. s_s_wnc1_s396 + PRICKLE1|​pho@Cytoplasm map + PAR6*@Cytoplasm map map PRICKLE1|​pho:​VANGL*@Cytoplasm map
  8. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​ROR2|​S864_emp|​emp|​emp:​SYN4*:​VANGL*|​emp|​emp|​emp|​emp:​_beta_-Arrestin2*@Cytoplasm map
  9. SMURF1@Cytoplasm map + CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  10. CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map map CK1_epsilon_*:​CTHRC1:​DVL*|​pho|​emp|​emp:​PRICKLE1|​pho|​ubi:​PRR*:​ROR2:​SYN4*:​VANGL*:​_beta_-Arrestin2*@Cytoplasm map
  11. PRICKLE1|​pho|​ubi@Cytoplasm map map degraded

As Catalyser:

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