Identifiers
AKT1 substrate 1 (proline-rich)
HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1
Maps_Modules
Apoptosis / AKT_MTOR
Survival / PI3K_AKT_MTOR
References
synonym:PRAS
PMID:18372248
PMID:17604271
PRAS40*|S183_pho|T246_pho|S212_pho|S221_pho@Membrane Lysosome
References
s_akt1_re58( Survival ):
PMID:19446321
ANNOTATION:complex formation with DEPTOR antagonize/inhibits MTOR kinase activity
PMID:19706736
s_akt1_re61:( Survival ) PMID:17604271
Modifications:
In compartment: Cytoplasm
In compartment: Membrane Lysosome
Participates in complexes:
In compartment: Cytoplasm
- 14-3-3*|unk:PRAS40*|pho@Cytoplasm
- MLST8:MTOR:PRAS40*:RPTOR@Cytoplasm
- MLST8:MTOR:PRAS40*|pho:RPTOR@Cytoplasm
In compartment: Membrane Lysosome
- 14-3-3*:PRAS40*|S183_pho|T246_pho|S212_pho|S221_pho@Membrane Lysosome
- MLST8:MTOR|S2448_emp:PRAS40*:RAC1:RPTOR@Membrane Lysosome
- MLST8:MTOR|S2448_pho:PRAS40*:RAC1:RPTOR@Membrane Lysosome
- MLST8:MTOR|S1261_pho|S2448_emp:PRAS40*:RAC1:RPTOR@Membrane Lysosome
- MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*:RAC1:RPTOR@Membrane Lysosome
- MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*|S183_emp|T246_emp:RAC1:RPTOR|S696_pho|T706_pho|S863_pho|S877_pho@Membrane Lysosome
- MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*|S183_emp|T246_emp:RAC1:RPTOR|S696_pho|T706_pho|S855_pho|S863_pho|S877_pho|S859_pho@Membrane Lysosome
- MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*|S183_pho|T246_pho|S212_pho|S221_pho:RAC1:RPTOR|S696_pho|T706_pho|S855_pho|S863_pho|S877_pho|S859_pho@Membrane Lysosome
Participates in reactions:
As Reactant or Product:
- MLST8:MTOR:RPTOR@Cytoplasm
+ PRAS40*@Cytoplasm
→
MLST8:MTOR:PRAS40*:RPTOR@Cytoplasm
- MLST8:MTOR:PRAS40*:RPTOR@Cytoplasm
→
MLST8:MTOR:PRAS40*|pho:RPTOR@Cytoplasm
- 14-3-3*|unk@Cytoplasm
+ MLST8:MTOR:PRAS40*|pho:RPTOR@Cytoplasm
→
MLST8:MTOR:RPTOR@Cytoplasm
+ 14-3-3*|unk:PRAS40*|pho@Cytoplasm
- PRAS40*@Cytoplasm
+ MLST8@Cytoplasm
+ RPTOR@Cytoplasm
+ MTOR|S2448_pho@Cytoplasm
→
MLST8:MTOR|S2448_pho:PRAS40*:RAC1:RPTOR@Membrane Lysosome
- PRAS40*@Cytoplasm
+ MLST8@Cytoplasm
+ RPTOR@Cytoplasm
+ MTOR@Cytoplasm
+ RAC1@Cytoplasm
→
s_s_akt1_s873
- 14-3-3*:PRAS40*|S183_pho|T246_pho|S212_pho|S221_pho@Membrane Lysosome
→
s_s_akt1_s595
- s_s_akt1_s873 →
MLST8:MTOR|S2448_emp:PRAS40*:RAC1:RPTOR@Membrane Lysosome
- MLST8:MTOR|S2448_emp:PRAS40*:RAC1:RPTOR@Membrane Lysosome
→
MLST8:MTOR|S1261_pho|S2448_emp:PRAS40*:RAC1:RPTOR@Membrane Lysosome
- MLST8:MTOR|S1261_pho|S2448_emp:PRAS40*:RAC1:RPTOR@Membrane Lysosome
→
MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*:RAC1:RPTOR@Membrane Lysosome
- MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*:RAC1:RPTOR@Membrane Lysosome
→
MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*|S183_emp|T246_emp:RAC1:RPTOR|S696_pho|T706_pho|S863_pho|S877_pho@Membrane Lysosome
- MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*|S183_emp|T246_emp:RAC1:RPTOR|S696_pho|T706_pho|S863_pho|S877_pho@Membrane Lysosome
→
MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*|S183_emp|T246_emp:RAC1:RPTOR|S696_pho|T706_pho|S855_pho|S863_pho|S877_pho|S859_pho@Membrane Lysosome
- MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*|S183_emp|T246_emp:RAC1:RPTOR|S696_pho|T706_pho|S855_pho|S863_pho|S877_pho|S859_pho@Membrane Lysosome
→
MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*|S183_pho|T246_pho|S212_pho|S221_pho:RAC1:RPTOR|S696_pho|T706_pho|S855_pho|S863_pho|S877_pho|S859_pho@Membrane Lysosome
- MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*|S183_pho|T246_pho|S212_pho|S221_pho:RAC1:RPTOR|S696_pho|T706_pho|S855_pho|S863_pho|S877_pho|S859_pho@Membrane Lysosome
→
MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:RAC1:RPTOR|S696_pho|T706_pho|S855_pho|S863_pho|S877_pho|S859_pho@Membrane Lysosome
+ PRAS40*|S183_pho|T246_pho|S212_pho|S221_pho@Membrane Lysosome
- PRAS40*|S183_pho|T246_pho|S212_pho|S221_pho@Membrane Lysosome
+ 14-3-3*@Cytoplasm
→
14-3-3*:PRAS40*|S183_pho|T246_pho|S212_pho|S221_pho@Membrane Lysosome
As Catalyser:
- MLST8:MTOR|S1261_pho|S2448_emp:PRAS40*:RAC1:RPTOR@Membrane Lysosome
→
MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*:RAC1:RPTOR@Membrane Lysosome
- MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*:RAC1:RPTOR@Membrane Lysosome
→
MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*|S183_emp|T246_emp:RAC1:RPTOR|S696_pho|T706_pho|S863_pho|S877_pho@Membrane Lysosome
- MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*|S183_emp|T246_emp:RAC1:RPTOR|S696_pho|T706_pho|S855_pho|S863_pho|S877_pho|S859_pho@Membrane Lysosome
→
MLST8:MTOR|S1261_pho|S2448_emp|S2481_pho:PRAS40*|S183_pho|T246_pho|S212_pho|S221_pho:RAC1:RPTOR|S696_pho|T706_pho|S855_pho|S863_pho|S877_pho|S859_pho@Membrane Lysosome