PPP5C

Protein PPP5C map

Identifiers
protein phosphatase 5, catalytic subunit
HUGO:PPP5C HGNC:9322 ENTREZ:5536 UNIPROT:P53041 GENECARDS:PPP5C KEGG:5536 ATLASONC:GC_PPP5C WIKI:PPP5C

Maps_Modules
 Apoptosis  map  / TNF_RESPONSE  map
 DNA repair  map  / S_PHASE_CHECKPOINT  map

References
PMID:15459660, PMID:16260606, PMID:14871926

PPP5C@Cytoplasm

References
a_re1324( Apoptosis  map ):
PMID:11689443
in 293T, in Hela, in L929, interaction between ectopically expressed tagged ASK1 and PPP5
in Hela, PPP5 expression inhibits ASK1 activity
in vitro, purified ASK1 dephosphorylated by recombinant PPP5

PPP5C@default

References
d_re36( DNA repair  map ):
PMID:16332722
Auto-phosphorylation of ATM in response to DNA DSB:
PMID:17303408, PMID:12556884, PMID:16858402
Amplification of ATM auto-phosphorylation by the complex ATM:MRNcomplex:H2AX:MDC1CDK5 phosphorylates and activates ATM
PMID:19151707
d_re119( DNA repair  map ):
For inhibition of S-checkpoint by ATM:
PMID:15175241, PMID:12086603
For inhibition of S-checkpoint by HCLK2/FAAP24/ATR/FANKM complex:
PMID:19282663, PMID:19622404, PMID:18995830
For interaction between SNM1B and ATM to mediate S-phase checkpoint in response to ICL (intra-chromatide lesion):
PMID:18469862
Resected DNA is a triger for activating the S-phase checkpoint and moving from G1 to S to G2:
PMID:20051983, PMID:16805667
For inhibition of S to G2 propagation and activation of S-phase checkpoint by complex PCNA:CtIP:
PMID:19342888
ATR kinase activation mediated by MutSalpha and MutLalpha in response to cytotoxic O6-methylguanine adducts. O6-methylguanine adducts recognized by MutSalpha, MutLalpha and BER pathways performs the repair. ATR/ATRIP S phase arrest is activated:
PMID:16713580
For role of TIM1*/TIPIN in S-phase checkpoint, stalled replication forks stabilisation and DNA repair during S-phase:
PMID:17102137, PMID:17116885, PMID:17296725, PMID:19793801, PMID:17582221
For inhibition of S-phase by ATR/ATRIP/CHEK1/CLSPN/HCLK2* complex:
PMID:19793801, PMID:17384638
For ATR/ATRIP/CHEK1/Tim* S-phase checkpoint
PMID:15798197
Formation of the complex for crosslink-activation of S phase checkpoint. FA core complex activates the reaction to stop S-phase propagaton:
PMID:14988723, PMID:15136767


Modifications:
In compartment: Cytoplasm
  1. PPP5C@Cytoplasm map

In compartment: default

  1. PPP5C@default map

Participates in complexes:
In compartment: default

  1. PPP5C:​RAD17@default map

Participates in reactions:
As Reactant or Product:

  1. PPP5C@default map + RAD17@default map map PPP5C:​RAD17@default map

  2. PPP5C:​RAD17@default map map PPP5C@default map + RAD17@default map

As Catalyser:

  1. ASK1*|​pho|​oligomer@Cytoplasm map map ASK1*|​oligomer@Cytoplasm map

  2. S phase@default map map G2 phase@default map
  3. ATM@default map map ATM|​pho|​S367_pho|​S1893_pho|​active@default map

Leave a Reply