PPP1C*

Protein PPP1C* map

Identifiers
protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1A, “protein phosphatase 1, catalytic subunit, alpha isoform”
HUGO:PPP1CA HGNC:9281 ENTREZ:5499 UNIPROT:P62136 GENECARDS:PPP1CA REACTOME:61996 KEGG:5499 ATLASONC:GC_PPP1CA WIKI:PPP1CA
protein phosphatase 1, catalytic subunit, beta isozyme
HUGO:PPP1CB HGNC:9282 ENTREZ:5500 UNIPROT:P62140 GENECARDS:PPP1CB REACTOME:62004 KEGG:5500 ATLASONC:GC_PPP1CB WIKI:PPP1CB
protein phosphatase 1, catalytic subunit, gamma isozyme
HUGO:PPP1CC HGNC:9283 ENTREZ:5501 UNIPROT:P36873 GENECARDS:PPP1CC REACTOME:62014 KEGG:5501 ATLASONC:GC_PPP1CC WIKI:PPP1CC

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / ADHERENS_JUNCTIONS  map
 Apoptosis  map  / MITOCH_METABOLISM  map
 Apoptosis  map  / MOMP_REGULATION  map
 Cell cycle  map  / RB  map
 Survival  map  / WNT_CANONICAL  map

References
catalytic subunit of phosphatase PP1A, PP1c
3 genes encode 3 isoforms
Anaphase-specific phosphatase
PMID:20399103

PPP1C*@Cytoplasm

References
e_re1016( EMT  map ):
PMID:17318175
PPP1 regulates assembly and function of the CTNNB1 degradation complex.
PPP1 reverses CSNK1 (casein kinase 1) – mediated phosphorylation of AXIN1.
This dephosphorylation allows CTNNB1 to escape the degradation complex of AXIN1 and APC.


Modifications:
In compartment: Cytoplasm
  1. PPP1C*@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. PPP1C*:​PPP1R*@Cytoplasm map

  2. AXIN*|​S80_emp|​S82_emp|​S222_emp|​S473_emp:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map
  3. AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map

In compartment: Mitochondrial outer membrane

  1. BAD|​S91_unk:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial outer membrane map

  2. BAD|​S91_unk|​pho:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial outer membrane map

In compartment: Nucleus

  1. PPP1C*:​PPP1R*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. BAD|​S91_unk|​active@Cytoplasm map + GCK@Cytoplasm map + WASF1@Cytoplasm map + PRKAC*@Cytoplasm map + PPP1C*@Cytoplasm map map BAD|​S91_unk:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial outer membrane map

  2. BAD|​S91_unk:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial outer membrane map map BAD|​S91_unk|​pho:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial outer membrane map
  3. BAD|​S91_unk|​pho:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial outer membrane map map BAD|​S91_unk:​GCK:​PPP1C*:​PRKAC*:​WASF1@Mitochondrial outer membrane map
  4. PPP1C*@Cytoplasm map map PPP1CA@Cytoplasm map
  5. PPP1C*@Cytoplasm map map PPP1CB@Cytoplasm map
  6. PPP1C*@Cytoplasm map map PPP1CC@Cytoplasm map
  7. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map + PPP1C*:​PPP1R*@Cytoplasm map map AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map
  8. AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map map AXIN*|​S80_emp|​S82_emp|​S222_emp|​S473_emp:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map
  9. AXIN*|​S80_emp|​S82_emp|​S222_emp|​S473_emp:​CK1_alpha_*:​GSK3*:​PPP1C*:​PPP1R*@Cytoplasm map map GSK3*@Cytoplasm map + AMER1*:​AXIN*:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map + PPP1C*:​PPP1R*@Cytoplasm map

As Catalyser:

  1. glucose@Cytoplasm map + ATP@Cytoplasm map map glucose-6P@Cytoplasm map + ADP@Cytoplasm map

  2. RB1|​pho|​pho|​pho@Nucleus map map RB1@Nucleus map
  3. (APC|​pho:​AXIN1|​pho)|​active@Cytoplasm map map APC:​AXIN1@Cytoplasm map

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