PP2A_C*

Protein PP2A_C* map

Identifiers
protein phosphatase 2 catalytic subunit alpha isozyme
HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA
P67775
protein phosphatase 2 catalytic subunit beta isozyme
HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB
P62714
“protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform”

Maps_Modules
 Survival  map  / HEDGEHOG  map
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_CANONICAL  map

References
PMID:18042541
PMID:10995457
PMID:16680151
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex.
PMID:18039929
PMID:18588945

PP2A_C*|​unk@Cytoplasm

References
s_mpk1_re194( Survival  map ):
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex.
PMID:18039929
s_mpk1_re189( Survival  map ):
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
s_s_mpk1_re189( Survival  map ):

PP2A_C*@Cytoplasm

References
s_mpk1_re194( Survival  map ):
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex.
PMID:18039929


Modifications:
In compartment: Cytoplasm
  1. PP2A_C*@Cytoplasm map

  2. PP2A_C*|​unk@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. PP2A_C*:​PR55_alpha_*:​PR65_A*@Cytoplasm map

  2. PP2A_A*:​PP2A_B55_alpha_*:​PP2A_C*@Cytoplasm map
  3. PP2A_A*:​PP2A_B55_alpha_*:​PP2A_C*@Cytoplasm map
  4. AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm map
  5. AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map

In compartment: Nucleus

  1. PP2A_A*:​PP2A_B*:​PP2A_C*@Nucleus map

  2. DAXX:​PML:​PP2A_A*:​PP2A_B*:​PP2A_C*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. PP2A_A*:​PP2A_B*:​PP2A_C*@Nucleus map map PP2A_A*:​PP2A_B*:​PP2A_C*@Nucleus map

  2. PP2A_A*:​PP2A_B*:​PP2A_C*@Nucleus map + DAXX:​PML@Nucleus map map DAXX:​PML:​PP2A_A*:​PP2A_B*:​PP2A_C*@Nucleus map
  3. PP2A_C*@Cytoplasm map map PP2A_C*|​unk@Cytoplasm map
  4. AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map + PP2A_C*:​PR55_alpha_*:​PR65_A*@Cytoplasm map map AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map
  5. AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_pho|​T41_pho|​S37_pho|​S33_pho@Cytoplasm map map AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm map
  6. AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PP2A_C*:​PR55_alpha_*:​PR65_A*:​_beta_-Catenin*|​S45_emp|​T41_emp|​S37_emp|​S33_emp@Cytoplasm map map PP2A_C*:​PR55_alpha_*:​PR65_A*@Cytoplasm map + _beta_-Catenin*@Cytoplasm map + AMER1*:​AXIN*|​S80_pho|​S82_pho|​S222_pho|​S473_pho|​S614_pho|​S621_pho:​CK1_alpha_*:​GSK3*:​PtdIns(4,5)-P2@Cytoplasm map

As Catalyser:

  1. AKT1|​T308_pho|​T450_pho|​S473_emp:​PI3,4,5-P3@Lipid Raft map map AKT1|​T450_pho|​S473_emp|​active@Cytoplasm map

  2. AKT*|​pho|​pho|​pho|​active@Nucleus map map AKT*|​emp|​pho|​pho@Nucleus map
  3. ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map map KSR1:​MEK*@Cytoplasm map + ERK*@Cytoplasm map
  4. MEK*|​pho|​pho@Cytoplasm map map MEK*@Cytoplasm map
  5. ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map map MEK*:​SEF*@Cytoplasm map + ERK*@Cytoplasm map
  6. ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map map MEK*:​_beta_-Arrestin2*@Cytoplasm map + ERK*@Cytoplasm map
  7. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*@Cytoplasm map + RAF1@Cytoplasm map
  8. GLI3-190*|​S849_emp|​S880_unk|​active@Primary Cilium map map GLI3-190*|​S849_emp|​S880_unk|​active@Nucleus map

Leave a Reply