POLZ*

Protein POLZ* map

Identifiers
REV3-like, catalytic subunit of DNA polymerase zeta (yeast)
HUGO:REV3L HGNC:9968 ENTREZ:5980 UNIPROT:O60673 GENECARDS:REV3L KEGG:5980 ATLASONC:GC_REV3L WIKI:REV3L

Maps_Modules
 DNA repair  map  / FANCONI  map
 DNA repair  map  / TLS  map

References
Related to the B-family polymerases. The first subunit of the Pol zeta complex (the second subunit is REV7)
PMID:19686080, PMID:19622404, PMID:18931676
PMID:23065650

POLZ*@default

References
d_re163( DNA repair  map ):
PMID:19686080
POLH activates D-loop extention
PoLN:HEL308* participate in HR and Fanconi. PolN:FANCD2:FANCI complex activate HR:
PMID:16337602
Presence of FA core complex is essential for thePolZ/Rev1 activity:
PMID:18448394
PoLQ/HEL308 in Fancon:
PMID:18472307
d_re489( DNA repair  map ):
Reaction (id=re180, name=; CellCycle_DNArepair_18_12_2010_Version3.xml)
Phosphorilated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
PMID:17035102
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
PMID:19225445
REV1 interacts with many TLS polymerases:
PMID:14657033
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158
For TLS
PMID:19258535
FA core complex regulates REV1 and activated TLS
PMID:22266823


Modifications:
In compartment: default
  1. POLZ*@default map

Participates in complexes:
In compartment: default

  1. PCNA|​K164_ubi:​POLZ*@default map

Participates in reactions:
As Reactant or Product:

  1. PCNA|​K164_ubi@default map + POLZ*@default map map PCNA|​K164_ubi:​POLZ*@default map

As Catalyser:

  1. gFanconi_DNA_st4*@Nucleus map map gFanconi_DNA_st5*@Nucleus map

  2. gTLS_DNA_st1*@Nucleus map map gTLS_DNA_st2*@Nucleus map

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