POLI

Protein POLI map

Identifiers
polymerase (DNA directed) iota
HUGO:POLI HGNC:9182 ENTREZ:11201 UNIPROT:Q9UNA4 GENECARDS:POLI KEGG:11201 ATLASONC:GC_POLI WIKI:POLI

Maps_Modules
 DNA repair  map  / TLS  map

References
PMID:18196958, PMID:17652783
Related to the Y-family polymerases
PMID:19258535
Bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta
PMID:15189446, PMID:12466554

POLI@default

References
d_re114( DNA repair  map ):
PMID:18171670, PMID:20064462
For regulation of HR by cell cycle. CDK1 is essential to switch cells from C_NHEJ to HR during S/G2 phase: PMID:15496928
The complex BRCA2:FANCC:FANCG:XRCC3 activates HR:
PMID:18212739
For role of BLM:TOP3:RMI1 complex in the HR resection step:
PMID:19490890
For central role of the MRN complex and CtIP in the resection of the DNA that turns on the HR and off C_NHEJ:
PMID:20021983
For inhibition of HR by RECQ5:
PMID:19270065
For role of CDC2 (CDK1) in DNA resection initiation in S/G2 phase, HR initiation:
PMID:15655342, PMID:15549137, PMID:15496928
RNF8:MDC1 complex recruit HR-related proteins by this shifting from C_NHEJ to HR:
PMID:18001825
SUMOlated PCNA recognizes stalled replication fork and blocks homologous recombination, re-orients toward TLS
PMID:19217833


Modifications:
In compartment: default
  1. POLI@default map

Participates in complexes:
In compartment: default

  1. PCNA|​K164_ubi:​POLI:​REV1@default map

Participates in reactions:
As Reactant or Product:

  1. PCNA|​K164_ubi@default map + POLI@default map + REV1@default map map PCNA|​K164_ubi:​POLI:​REV1@default map

As Catalyser:

  1. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map

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