POLH

Protein POLH map

Identifiers
polymerase (DNA directed), eta
HUGO:POLH HGNC:9181 ENTREZ:5429 UNIPROT:Q9Y253 GENECARDS:POLH REACTOME:110286 KEGG:5429 ATLASONC:XPVID303 WIKI:POLH

Maps_Modules
 DNA repair  map  / TLS  map
 DNA repair  map  / HR  map
 DNA repair  map  / FANCONI  map

References
PMID:18196958, PMID:17652783
Related to the Y-family polymerases
PMID:19258535
POLH participates in the D-loop formation in HR
PMID:16337602, PMID:16337601
Bypasses thymidine-thymidine (T-T) cyclobutane pyrimidine dimer (CPD) very accurately
PMID:15189446
Cisplatin tolerance in cells with active POLH
PMID:22562137

POLH@default

References
d_re139( DNA repair  map ):
PMID:19686080
POLH participates in the D-loop formation in HR:
PMID:16337602, PMID:16337601
Complex PolN:HEL308 participates in HR and in Fanconi PMID:19995904
d_re236( DNA repair  map ):
Recruitment of all components as POLH and RAD6/RAD18 that ubiguitinate PCNA all together activate TLS:
PMID:16824193
d_re252( DNA repair  map ):
Requirement for functional DNA polymerase eta in genome-wide repair by NER of UV-induced DNA damage during S phase:
PMID:20457011
Link between Fanconi and NER
PMID:22615860


Modifications:
In compartment: default
  1. POLH@default map

Participates in complexes:
In compartment: default

  1. PCNA|​K164_ubi:​POLH:​REV1@default map

  2. POLH:​RAD18:​RAD6*:​REV1@default map

Participates in reactions:
As Reactant or Product:

  1. RAD18:​RAD6*@default map + POLH@default map + REV1@default map map POLH:​RAD18:​RAD6*:​REV1@default map

  2. REV1@default map + PCNA|​K164_ubi@default map + POLH@default map map PCNA|​K164_ubi:​POLH:​REV1@default map

As Catalyser:

  1. gHR_DNA_st3*@Nucleus map map gHR_DNA_st4*@Nucleus map

  2. gGG-NER_DNA_st1*@Nucleus map map gGG-NER_DNA_st2*@Nucleus map
  3. gTLS_DNA_st1*@Nucleus map map gTLS_DNA_st2*@Nucleus map

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