POLB

Protein POLB map

Identifiers
PolB, polymerase (DNA directed), beta
HUGO:POLB HGNC:9174 ENTREZ:5423 UNIPROT:P06746 GENECARDS:POLB REACTOME:53846 KEGG:11232 ATLASONC:GC_POLB WIKI:POLB

Maps_Modules
 DNA repair  map  / BER  map

References
PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013
POLB is important for repair of ROS-induced DNA damage, inhibiting impoves sensitivity to ROS-like drugs
PMID:20510258, PMID:21251944

POLB@default

References
d_re2:( DNA repair  map ) deoxyribose-phosphatase activity of PolB
d_re7:( DNA repair  map ) deoxyribose 5′-phosphatase activity of PolB
d_re22( DNA repair  map ):
PMID:18398454
PMID:16449207
RECQL5 activates BER via XRCC1 and PARP1
PMID:22973052


Modifications:
In compartment: default
  1. POLB@default map

Participates in complexes:
In compartment: default

  1. PARP2|​unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default map

  2. PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default map
  3. PARP1:​PCNA:​POLB:​POLD*:​POLE*:​RFC*@default map

Participates in reactions:
As Reactant or Product:

  1. POLB@default map + PCNA@default map + POLE*@default map + POLD*@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map + RFC*@Nucleus map map PARP1:​PCNA:​POLB:​POLD*:​POLE*:​RFC*@default map

  2. POLB@default map + XRCC1|​pho@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map + WRN|​ace@default map + PNK*@default map map PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default map
  3. PARP2|​unk|​pho@default map + WRN|​ace@default map + PNK*@default map + XRCC1|​pho@default map + POLB@default map map PARP2|​unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default map

As Catalyser:

  1. gBER_M-glyc_DNA_st3*@Nucleus map map gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus map + 5′dRP@default map

  2. gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus map + dNTPs@Nucleus map map gShP_BER_M-glyc_st5_B-glyc_DNA_st5*@Nucleus map
  3. gBER_M-glyc_DNA_st3*@Nucleus map + dNTPs@default map map gLnP_BER_M-glyc_st4*@Nucleus map
  4. gBER_B-glyc_DNA_st2*@Nucleus map map gBER_B-glyc_DNA_st3*@Nucleus map

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