PLK1

Protein PLK1 map

Identifiers
polo-like kinase 1 (Drosophila)
HUGO:PLK1 HGNC:9077 ENTREZ:5347 UNIPROT:P53350 GENECARDS:PLK1 REACTOME:69858 KEGG:5347 ATLASONC:PLK1ID41747ch16p12 WIKI:PLK1

Maps_Modules
 DNA repair  map  / G2_M_CHECKPOINT  map

References
For Fanconi anemia pathway
PMID:19686080, PMID:19622404, PMID:18931676
FANCM is phosphorylated by PLK1 and beta-TRCP in response to G2/M checkpoint.
Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156

PLK1|​pho|​active@default

References
d_re194( DNA repair  map ):
FANCM is phosphorylated by PLK1 and ubiquitinated by beta-TRCP (in the SCF complex) in response to G2/M checkpoint. Phosphorylated FANCM is degraded and FANCONI pathway is inhibited during mitosis.
PMID:19270156, PMID:19686080
d_re313( DNA repair  map ):
Activation by PLK phosphorylation at S191, S198
Activation by CDC2 phosphorylation at S214
PMID:17596790
d_re449:( DNA repair  map ) PMID:11073952


Modifications:
In compartment: default
  1. PLK1@default map

  2. PLK1|​pho|​active@default map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. PLK1@default map map PLK1|​pho|​active@default map

    As Catalyser:

    1. FANCM@default map map FANCM|​pho@default map

    2. WEE1|​CHEK1site_pho@Nucleus map map WEE1|​pho@default map
    3. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*@default map map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​E-Cadherin*|​pho@default map
    4. APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20@default map map APC1*:​APC10*:​APC11*:​APC12*:​APC2*:​APC3*:​APC4*:​APC5*:​APC6*:​APC7*:​APC8*:​CDC20|​pho:​CyclinA1*@default map
    5. CDC25B@default map map CDC25B|​S353_pho|​active@default map
    6. CDC25C@default map map CDC25C|​S191_pho|​S198_pho|​S214_pho|​active@default map
    7. EMI1*@default map map EMI1*|​pho@default map
    8. MYC@default map + MIZ1*@default map + PKMYT1@Nucleus map map (MIZ1*:​MYC:​PKMYT1|​pho)|​active@default map
    9. STAG*@default map map STAG*|​pho@default map
    10. SCC1*@default map map SCC1*|​PLK1-dep._pho@default map

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