PIK3C3

Protein PIK3C3 map

Identifiers
phosphatidylinositol 3-kinase, catalytic subunit type 3
HUGO:PIK3C3 HGNC:8974 ENTREZ:5289 UNIPROT:Q8NEB9 GENECARDS:PIK3C3 REACTOME:188006 KEGG:5289 ATLASONC:GC_PIK3C3 WIKI:PIK3C3

Maps_Modules
 Apoptosis  map  / AKT_MTOR  map

References
synonym:VPS34

PIK3C3@Cytoplasm

References
a_re375( Apoptosis  map ):
PMID:15146184
inhibition relieved in mouse model of Huntington disease, where mTOR is inhibited by sequestration into polyglutamine aggregates
PMID:16839881
p53 target gene DRAM1 is necessary for induction of autophagy
PMID:20424262
by ammonia
a_re650( Apoptosis  map ):
in vitro by CASP3, CASP7, CASP8
in Ba/F3 upon IL3 deprivation, in FDCP1 upon IL3 deprivation, in U937 upon serum starvation, z-VAD-fmk inhibitable cleavage


Modifications:
In compartment: Cytoplasm
  1. PIK3C3@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. PIK3C3@Cytoplasm map map cleaved~PIK3C3*@Cytoplasm map

    As Catalyser:

    1. degraded map Autophagy@Cytoplasm map

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