PIAS1

Protein PIAS1 map

Identifiers
Protein inhibitor of activated STAT 1
HUGO:PIAS1 HGNC:2752 ENTREZ:8554 UNIPROT:O75925 GENECARDS:PIAS1 REACTOME:61690 KEGG:8554 ATLASONC:GC_PIAS1 WIKI:PIAS1
DDXBP1 “DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1″

Maps_Modules
 Survival  map  / HEDGEHOG  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:20711444

PIAS1@Primary Cilium

References
s_shh1_re76( Survival  map ):
PMID:20711444
PTM=sumoylation N/A in CellDesigner.
Sumoylation not detected on endogenous Gli proteins.
PKA antagonise sumoylation due to the consequence of PKA phosphorylation on Gli proteins it is not a direct effect of PKA. Exact

PIAS1@Nucleus

References
s_wnc3_re16( Survival  map ):
Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a “?”. Lys684 is targeted firstly, followed by Lys897.
PMID:15117942
s_wnc3_re18( Survival  map ):
Order of sumoylation is not important.
PMID:19218564


Modifications:
In compartment: Nucleus
  1. PIAS1@Nucleus map

  2. PIAS1@Nucleus map

In compartment: Primary Cilium

  1. PIAS1@Primary Cilium map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

      As Catalyser:

      1. GLI2-185*|​pho|​active@Primary Cilium map map GLI2-185*|​S805_unk|​pho|​active@Primary Cilium map

      2. GLI3-190*|​S849_emp|​active@Primary Cilium map map GLI3-190*|​S849_emp|​S880_unk|​active@Primary Cilium map
      3. s_s_wca3_s454 map CTBP*:​KLF8|​K67_unk@Nucleus map
      4. NFAT1*@Nucleus map map NFAT1*|​unk@Nucleus map
      5. NFAT1*|​unk@Nucleus map map NFAT1*|​unk|​unk@Nucleus map
      6. NFAT2*@Nucleus map map NFAT2*|​K702_unk|​K914_unk@Nucleus map

      85 thoughts on “PIAS1

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