Complex PCNA:REV1 map

Complex composition:

  1. PCNA map
  2. REV1 map



 DNA repair  map  / TLS  map

d_re173( DNA repair  map ):
REV1 interacts with ubiquitinated PCNA, this activates TLS:
d_re489( DNA repair  map ):
Reaction (id=re180, name=; CellCycle_DNArepair_18_12_2010_Version3.xml)
Phosphorilated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
REV1 interacts with many TLS polymerases:
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158
FA core complex regulates REV1 and activated TLS


Participates in complexes:
In compartment: default
  1. PCNA|​K164_ubi:​REV1@default map

Participates in reactions:
As Reactant or Product:

  1. PCNA|​K164_ubi@default map + REV1@default map map PCNA|​K164_ubi:​REV1@default map

As Catalyser:

  1. gTLS_DNA_st1*@Nucleus map map gTLS_DNA_st2*@Nucleus map

39 thoughts on “PCNA:REV1

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