PCNA:POLH:REV1

Complex PCNA:POLH:REV1 map


Complex composition:

  1. POLH map
  2. PCNA map
  3. REV1 map




PCNA|​K164_ubi:​POLH:​REV1@default

Identifiers
NAME:PCNA:POLH:REV1

Maps_Modules
 DNA repair  map  / TLS  map

References
PMID:19258535
d_re489( DNA repair  map ):
Reaction (id=re180, name=; CellCycle_DNArepair_18_12_2010_Version3.xml)
Phosphorilated Rev1 is the activator and the modulator of the TLC pathway in response to DNA damage and by cell cycle regulation
PMID:17035102
Several TLS polymerases participate in Fanconi in combination with HR and NER
PoL iota bypasses T-T adducts and dA-N6_BPDE, but only with assistance of Polkappa or Pol zeta:
PMID:15189446, PMID:12466554 (major)
Depending on the DNA damage, different TLS polymerases will be activated:
PMID:19225445
REV1 interacts with many TLS polymerases:
PMID:14657033
Polyubiquitination of PCNA activates prone-free mechanisms of lesions by-pass
PMID:19217833, PMID:18157158
For TLS
FA core complex regulates REV1 and activated TLS
PMID:22266823

Confidence
REF=5 FUNC=5


Modifications:
Participates in complexes:
In compartment: default
  1. PCNA|​K164_ubi:​POLH:​REV1@default map

Participates in reactions:
As Reactant or Product:

  1. REV1@default map + PCNA|​K164_ubi@default map + POLH@default map map PCNA|​K164_ubi:​POLH:​REV1@default map

As Catalyser:

  1. gTLS_DNA_st1*@Nucleus map map gTLS_DNA_st2*@Nucleus map

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