PARP3

Protein PARP3 map

Identifiers
poly (ADP-ribose) polymerase 3
HUGO:PARP3 HGNC:273 ENTREZ:10039 UNIPROT:Q9Y6F1 GENECARDS:PARP3 KEGG:10039 ATLASONC:GC_PARP3 WIKI:PARP3

Maps_Modules
 DNA repair  map  / HR  map
 DNA repair  map  / C_NHEJ  map

References
PMID:22055391
PARP3 activated spindle checkpoint and binds to double strand breaks together with PARP1
PMID:21270334
PARPs in cellular functions (PARP3 in telomere maintenance)
PMID:22713970, PMID:21270334
PARP3 in HR and C_NHEJ
PMID:22469522, PMID:196269035
PARP3 in chromatin remodeling
PMID:22469522, PMID:22713970
APLF and PARP3 in C_NHEJ
PMID:21211721
PMID:23178593
PMID:18077224
PARP3 in C_NHEJ
PMID:22743550

PARP3@Nucleus

References
d_re95:( DNA repair  map ) PMID:11955432, PMID:19772495

PARP3@default

References
d_re216( DNA repair  map ):
By CDC20/APC complex:
M to G1 transition
By Mitotic checkpoint complex:
Spindle checkpoint
PARP3 activated spindle checkpoint
PMID:21270334
Tankyrase activated spindle checkpoint
PMID:23197039
d_re540( DNA repair  map ):
PARPs in telomere maintenance
PMID:21818122, PMID:21076181, PMID:21037379


Modifications:
In compartment: Nucleus
  1. PARP3@Nucleus map

In compartment: default

  1. PARP3@default map

Participates in complexes:
In compartment: Nucleus

  1. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map

  2. APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map

In compartment: default

  1. PARP1|​PolyADPribose_unk|​pho:​PARP3@default map

Participates in reactions:
As Reactant or Product:

  1. PARP3@default map map Telomere maintenance@Nucleus map

  2. PARP3@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map map PARP1|​PolyADPribose_unk|​pho:​PARP3@default map
  3. PARP3@default map map Chromatin remodeling@Nucleus map
  4. Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + LIG4:​XLF*:​XRCC4|​hm2@default map + PARP3@Nucleus map + DNA-PK*|​hm2|​active@default map + Ku80*@default map + Ku70*@Nucleus map + APLF@Nucleus map map APLF:​Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​LIG4:​PARP3:​XLF*:​XRCC4|​hm2@Nucleus map
  5. DNA-PK*|​hm2|​active@default map + Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho|​active@default map + Ku70*:​Ku80*@Nucleus map + PARP3@Nucleus map map Artemis*|​S645_pho|​S385_pho|​S516_pho|​S518_pho:​DNA-PK*|​hm2:​Ku70*:​Ku80*:​PARP3@Nucleus map

As Catalyser:

  1. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map

  2. M phase@default map map G1 phase@default map
  3. gC_NHEJ_DNA_st3*@Nucleus map map gC_NHEJ_DNA_st4*@Nucleus map
  4. gC_NHEJ_DNA_st4*@Nucleus map map gC_NHEJ_DNA_st5*@Nucleus map

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