PARP2

Protein PARP2 map

Identifiers
poly (ADP-ribose) polymerase 2
HUGO:PARP2 HGNC:272 ENTREZ:10038 UNIPROT:Q9UGN5 GENECARDS:PARP2 KEGG:10038 ATLASONC:GC_PARP2 WIKI:PARP2
Q9UGN5

Maps_Modules
 DNA repair  map  / G1_S_CHECKPOINT  map
 DNA repair  map  / S_PHASE_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / BER  map
 DNA repair  map  / HR  map

References
NOTE:
PARP-? poly-ADP-ribosilated
PMID:22055391
PARP is active phosphorylated and poly-ADP-ribosilated form
PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072
PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce
PMID:22921416
PARPs in cellular functions
PMID:22713970
PARP1 and PARP2 in HR and in inhibition of C_NHEJ
PMID:22469522, PMID:196269035
PARP2 in chromatin remodeling
PMID:22469522, PMID:22713970

PARP2|​unk|​pho@default

References
d_re105( DNA repair  map ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737
d_re545( DNA repair  map ):
PMID:18398454
PMID:16449207
d_re549( DNA repair  map ):
PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce
PMID:22921416


Modifications:
In compartment: default
  1. PARP2@default map

  2. PARP2|​unk|​pho@default map

Participates in complexes:
In compartment: default

  1. PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map

  2. PARP2|​unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default map
  3. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map

Participates in reactions:
As Reactant or Product:

  1. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map map BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map

  2. PARP2|​unk|​pho@default map map PARP2@default map
  3. PARP2@default map map PARP2|​unk|​pho@default map
  4. PARP2|​unk|​pho@default map + WRN|​ace@default map + PNK*@default map + XRCC1|​pho@default map + POLB@default map map PARP2|​unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default map
  5. PARP2|​unk|​pho@default map map Oxidative stress@Nucleus map
  6. PARP2|​unk|​pho@default map map Mitochondria metabolism@Nucleus map
  7. PARP2|​unk|​pho@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map map PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map
  8. PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map map Telomere maintenance@Nucleus map
  9. PARP2|​unk|​pho@default map map Chromatin remodeling@Nucleus map

As Catalyser:

  1. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map

  2. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map
  3. gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus map + dNTPs@Nucleus map map gShP_BER_M-glyc_st5_B-glyc_DNA_st5*@Nucleus map
  4. gC_NHEJ_DNA_st1*@Nucleus map map gC_NHEJ_DNA_st2*@Nucleus map

Leave a Reply