PARP1

Protein PARP1 map

Identifiers
poly (ADP-ribose) polymerase 1
HUGO:PARP1 HGNC:270 ENTREZ:142 UNIPROT:P09874 GENECARDS:PARP1 REACTOME:62070 KEGG:142 ATLASONC:GC_PARP1 WIKI:PARP1
P09874

Maps_Modules
 DNA repair  map  / G1_S_CHECKPOINT  map
 DNA repair  map  / S_PHASE_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 DNA repair  map  / BER  map
 DNA repair  map  / HR  map
 DNA repair  map  / C_NHEJ  map
 DNA repair  map  / A_NHEJ  map

References
NOTE:
PARP-? poly-ADP-ribosilated
PMID:22055391
PARP is active phosphorylated and poly-ADP-ribosilated form
PMID:15703371, PMID:19847258, PMID:16697054, PMID:14726013, PMID:19208614, PMID:20603072
PARP1 and PARP2 modulate Mitochondria metabolism and oxidative stress responce
PMID:22921416
PARP3 activated spindle checkpoint and binds to double strand breaks together with PAPRP1
PMID:21270334
PARPs in cellular functions
PMID:22713970
PARP1 in chromatin remodeling
PMID:22469522, PMID:22713970
PARP1 initiating A_NHEJ (alt_NHEJ)
PMID:24050180
PMID:19364882
For A_NHEJ (alt_NHEJ or B_NHEJ or MMEJ):
PMID:21376743
PMID:22743550
PMID:23562323
PMID:24210699
Ku competes with PARP1 at the DNA binding site and inhibits alt_NHEJ
PMID:17088286
PMID:23145148
PMID:23568489

PARP1|​PolyADPribose_unk|​pho@Nucleus

References
d_re105( DNA repair  map ):
PMID:18584027, PMID:17965729, PMID:20064462, PMID:18809224
For inhibition of A_NHEJ by DNA-PKs:
PMID:15211575
For stimulation of A_NHEJ by PARP1:
PMID:15498778, PMID:19362533, PMID:24050180
For role of MRN complex in A_NHEJ:
PMID:19654615, PMID:19892829
BLM inhibits A_NHEJ (alt_NHEJ):
PMID:24089143
PMID:24095737

PARP1|​Ser782_pho|​Ser786_pho|​Ser785_pho@default

References
d_re555( DNA repair  map ):
Triple phosphorylation by CDK5 inhibits PARP1
PMID:21922195

PARP1@Nucleus

References
d_re555( DNA repair  map ):
Triple phosphorylation by CDK5 inhibits PARP1
PMID:21922195


Modifications:
In compartment: Nucleus
  1. PARP1@Nucleus map

  2. PARP1|​PolyADPribose_unk|​pho@Nucleus map

In compartment: default

  1. PARP1|​Ser782_pho|​Ser786_pho|​Ser785_pho@default map

Participates in complexes:
In compartment: Nucleus

  1. LIG3:​PARP1|​PolyADPribose_unk|​pho:​XRCC1|​pho@Nucleus map

In compartment: default

  1. PARP1:​p53*@default map

  2. H2AFX:​PARP1@default map
  3. CIP1_KIP1*:​PARP1@default map
  4. PARP1|​PolyADPribose_unk|​pho:​PARP3@default map
  5. PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map
  6. LIG1:​PARP1|​PolyADPribose_unk|​pho:​PCNA@default map
  7. PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default map
  8. PARP1:​PCNA:​POLB:​POLD*:​POLE*:​RFC*@default map
  9. BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map

Participates in reactions:
As Reactant or Product:

  1. POLB@default map + PCNA@default map + POLE*@default map + POLD*@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map + RFC*@Nucleus map map PARP1:​PCNA:​POLB:​POLD*:​POLE*:​RFC*@default map

  2. XRCC1|​pho@default map + LIG3@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map map LIG3:​PARP1|​PolyADPribose_unk|​pho:​XRCC1|​pho@Nucleus map
  3. BRCA1|​S988_pho|​S1387_pho|​S1423_pho|​S1497_pho|​S1524_pho:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi@default map + MRE11*:​NBS1*|​S343_pho:​RAD50@default map + PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map map BRCA1:​CTIP*|​emp|​S372_pho|​T847_pho|​S267_pho|​BRCA1-dep_ubi:​MRE11*:​NBS1*|​S343_pho:​PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho:​RAD50@default map
  4. POLB@default map + XRCC1|​pho@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map + WRN|​ace@default map + PNK*@default map map PARP1|​PolyADPribose_unk|​pho:​PNK*:​POLB:​WRN|​ace:​XRCC1|​pho@default map
  5. PCNA@default map + LIG1@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map map LIG1:​PARP1|​PolyADPribose_unk|​pho:​PCNA@default map
  6. PARP1@Nucleus map map PARP1|​PolyADPribose_unk|​pho@Nucleus map
  7. PARP1|​PolyADPribose_unk|​pho@Nucleus map map PARP1@Nucleus map
  8. H2AFX@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map map H2AFX:​PARP1@default map
  9. p53*@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map map PARP1:​p53*@default map
  10. CIP1_KIP1*@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map map CIP1_KIP1*:​PARP1@default map
  11. PARP1|​PolyADPribose_unk|​pho@Nucleus map map Oxidative stress@Nucleus map
  12. PARP1|​PolyADPribose_unk|​pho@Nucleus map map Mitochondria metabolism@Nucleus map
  13. PARP2|​unk|​pho@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map map PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map
  14. PARP3@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map map PARP1|​PolyADPribose_unk|​pho:​PARP3@default map
  15. PARP1@Nucleus map map PARP1|​Ser782_pho|​Ser786_pho|​Ser785_pho@default map
  16. PARP1|​PolyADPribose_unk|​pho:​PARP2|​unk|​pho@default map map Telomere maintenance@Nucleus map
  17. PARP1|​PolyADPribose_unk|​pho@Nucleus map map Chromatin remodeling@Nucleus map

As Catalyser:

  1. gA_NHEJ_DNA_st1*@Nucleus map map gA_NHEJ_DNA_st2*@Nucleus map

  2. gHR_DNA_st1*@Nucleus map map gHR_DNA_st2*@Nucleus map
  3. G1 phase@default map map S phase@default map
  4. gA_NHEJ_DNA_st5*@Nucleus map map gA_NHEJ_DNA_st6*@Nucleus map
  5. gHR_DNA_st6*@Nucleus map map gHR_DNA_st7*@Nucleus map
  6. gShP_BER_M-glyc_st5_B-glyc_DNA_st5*@Nucleus map map gShP_BER_M-glyc_st5_B-glyc_DNA_st6*@Nucleus map
  7. gLnP_BER_M-glyc_st5*@Nucleus map map gLnP_BER_M-glyc_st6*@Nucleus map
  8. gShP_BER_M-glyc_st4_B-glyc_DNA_st4*@Nucleus map + dNTPs@Nucleus map map gShP_BER_M-glyc_st5_B-glyc_DNA_st5*@Nucleus map
  9. gBER_M-glyc_DNA_st3*@Nucleus map + dNTPs@default map map gLnP_BER_M-glyc_st4*@Nucleus map
  10. SNAI1@Nucleus map map SNAI1|​unk@Nucleus map
  11. WRN@Nucleus map map WRN|​unk@default map
  12. gSingle_strand_breaks_SSB*@Nucleus map map gBER_B-glyc_DNA_st3*@Nucleus map
  13. gSingle_strand_breaks_SSB*@Nucleus map map gBER_M-glyc_DNA_st3*@Nucleus map
  14. gC_NHEJ_DNA_st1*@Nucleus map map gC_NHEJ_DNA_st2*@Nucleus map

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