PARD6A

Gene PARD6A map

Identifiers
par-6 partitioning defective 6 homolog alpha (C. elegans)
HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / TIGHT_JUNCTIONS  map

References
PMID:15761148
PARD6A is a regulator of epithelial cell polarity and tight-junction assembly
TGFBRI is localized to tight junctions where PARD6A is also found. TGFBR1 binds to PARD6A and localizes to tight junctions irrespective of TGF-beta stimulation.
The N-terminus of PARD6A, containing a PB1 domain necessary for binding to TGFBR1
TGFB stimulation induces redistribution of TGFBRII into tight junctions.
PARD6A interacts with TGFB receptors and is phsophorylated by TGFBRIII.
Phosphorylation of Par6 is required for TGFB-dependent EMT in mammary gland epithelial cells
This phosphorylation controls the interaction of PARD6A with the E3 ubiquitin ligase Smurf1.
Smurf1, in turn, targets GTPase RhoA for degradation, thereby leading to a loss of tight junctions.
PMID:22949611
Signaling molecules act directly on polarity proteins, bypassing transcription factors such as Snail and Zeb1:
TGFBRI binds to the tight junction protein Occludin and locally assembles into a complex containing Par6.
Activated TGFBRII phosphorylates Par6, which binds to Smurf1 and causes RhoA ubiquitylation and the dissolution of junctions.


Modifications:
In compartment: Nucleus
  1. gPARD6A@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gPARD6A@Nucleus map map rPARD6A@Nucleus map

    As Catalyser:

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