PAK1

Protein PAK1 map

Identifiers
p21 protein (Cdc42/Rac)-activated kinase 1
“p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)”, “p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)”
HUGO:PAK1 HGNC:8590 ENTREZ:5058 UNIPROT:Q13153 GENECARDS:PAK1 REACTOME:61276 KEGG:5058 ATLASONC:PAK1ID41633ch11q13 WIKI:PAK1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map
 Apoptosis  map  / MOMP_REGULATION  map

PAK1@Cytoplasm

References
e_re840( EMT  map ):
CDC42 promotes changes in actin cytoskeleton by several pathways.
PMID:10461188
PMID:11950587
PMID:11340065
PMID:10559936
PMID:10613909
PMID:11413130
CDC42 activates PAK1,2,3,4 and CDC42BPA (MRCKalpha) which phosphorylate LIMK1,2.
LIMK1,2 subsquently phosphorylate and inhibit Cofilin
Destrin as actin depolymerizing factor, once phosphorylated by LIMK1,2 is inactive and thus this phosphorylation leads to actin polymerization and stimulation of filopodia and stress fibers formation.
PMID:15713627
Spatially distinct binding of Cdc42 to PAK1 and N-WASP
e_re472( EMT  map ):
PMID:22154077, PMID:17522712
PMID:11018042
LIMK1 is regulated by Pak1,
e_re791( EMT  map ):
Rac1 binds to BAIAP2 which in turn associates with WASF2.
This stimulates ARP2/3 and leads to actin cytoskeleal polymerization.
PMID:16702231
WAVE2 (so-called WASF2) activates the ARP2/3 complex for Rac-induced actin polymerization during lamellipodium formation
PMID:9843499
WASF (WAVE) as regulator of actin reorganization downstream of Rac.
Expressed WAVE induces the formation of actin filament clusters.
WAVE plays a critical role downstream of Rac in regulating the actin cytoskeleton required for mem- brane ruffling
PMID:12054568
WAVE2 serves a functional partner of IRSp53 by regulating its interaction with Rac.
PMID:8625410
PMID:16293614
PMID:10467124
PMID:10511705
CDC42 induces actin cytoskeleton changes by activating WASP and N-WASP.
WASP and N-WASP binds to ARP2/3 and this lieads to actin cytoskeletal polymerization and filopodia formation.
PMID:14749719
PAK1 phosphorylates and activates ARP2_3 complex.
e_re964( EMT  map ):
PMID:11121431
PMID:15157156
PMID:15229651
Nischarin binds preferentially to the cytoplasmic tail of ITGA5 subunit ti inhibit cell migration.
Nischarin is not found in focal adhesion sites.
Once integrins enter into adhesion sites, Nischarin is released, allowing it to bind to the activated PAK1 in order to inactive PAK1..
This binding is enhaced by active Rac1.
The ability of Nischarin to inhibit PAK1 is related to its ability to inhibit cell motility.


Modifications:
In compartment: Cytoplasm
  1. PAK1@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. NISCH:​PAK1@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. PAK*|​pho|​active@Cytoplasm map map PAK1@Cytoplasm map

  2. PAK1@Cytoplasm map map PAK1@Cytoplasm map
  3. PAK*@Cytoplasm map map PAK1@Cytoplasm map
  4. PAK1@Cytoplasm map + NISCH@Nucleus map map NISCH:​PAK1@Cytoplasm map
  5. NISCH:​PAK1@Cytoplasm map map Cell migration@Cytoplasm map

As Catalyser:

  1. BAD@Cytoplasm map map BAD|​pho@Cytoplasm map

  2. LIMK1@Cytoplasm map map LIMK1|​pho|​active@Nucleus map
  3. ARP2_3*@Cytoplasm map map ARP2_3*@Cytoplasm map

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