PAK*

Protein PAK* map

Identifiers
PAK*
p21 protein (Cdc42/Rac)-activated kinase 1
“p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)”, “p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)”
HUGO:PAK1 HGNC:8590 ENTREZ:5058 UNIPROT:Q13153 GENECARDS:PAK1 REACTOME:61276 KEGG:5058 ATLASONC:PAK1ID41633ch11q13 WIKI:PAK1
p21 protein (Cdc42/Rac)-activated kinase 2
“p21 (CDKN1A)-activated kinase 2″
HUGO:PAK2 HGNC:8591 ENTREZ:5062 UNIPROT:Q13177 GENECARDS:PAK2 REACTOME:61278 KEGG:5062 ATLASONC:PAK2ID41634ch3q29 WIKI:PAK2
p21 protein (Cdc42/Rac)-activated kinase 3
“mental retardation, X-linked 47″, MRX30, MRX47, “p21 (CDKN1A)-activated kinase 3″
HUGO:PAK3 HGNC:8592 ENTREZ:5063 UNIPROT:O75914 GENECARDS:PAK3 REACTOME:401905 KEGG:5063 ATLASONC:GC_PAK3 WIKI:PAK3

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

PAK*@Cytoplasm

References
e_re761( EMT  map ):
PMID:8805275
PMID:8910277
PMID:9744077
PMID:10023776
PMID:11728826
GTP-bound Rac1 activates PAK1,2,3.
The binding of the active GTP form of Rac1 and the PBD domain of PAK1,2,3 promotes autophosphorylation of PAK1,2,3 and activation of JNK pathway.

PAK*|​pho|​active@Cytoplasm

References
e_re761( EMT  map ):
PMID:8805275
PMID:8910277
PMID:9744077
PMID:10023776
PMID:11728826
GTP-bound Rac1 activates PAK1,2,3.
The binding of the active GTP form of Rac1 and the PBD domain of PAK1,2,3 promotes autophosphorylation of PAK1,2,3 and activation of JNK pathway.
e_re762( EMT  map ):
The association between the active GTP-bound form of CDC42 and the PBD domain of PAK1,2,3,4 promotes PAK1,2,3,4 autophosphorylation
PMID:16204230
PMID:10461188
PMID:11950587
All 4 kinases PAK1,2,3,4 are capable of promoting JNK signaling activation that leads to cytoskeletal rearrangement and cell motility.


Modifications:
In compartment: Cytoplasm
  1. PAK*@Cytoplasm map

  2. PAK*|​pho|​active@Cytoplasm map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. PAK*|​pho|​active@Cytoplasm map map PAK1@Cytoplasm map

    2. PAK*|​pho|​active@Cytoplasm map map PAK2@Cytoplasm map
    3. PAK*|​pho|​active@Cytoplasm map map PAK3@Cytoplasm map
    4. PAK*@Cytoplasm map map PAK*|​pho|​active@Cytoplasm map
    5. PAK*|​pho|​active@Cytoplasm map map JNK pathway@Cytoplasm map
    6. PAK*@Cytoplasm map map PAK3@Cytoplasm map
    7. PAK*@Cytoplasm map map PAK2@Cytoplasm map
    8. PAK*@Cytoplasm map map PAK1@Cytoplasm map

    As Catalyser:

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