p70_alpha_*

Protein p70_alpha_* map

Identifiers
ribosomal protein S6 kinase 70kDa polypeptide 1
“ribosomal protein S6 kinase 70kD polypeptide 1″ STK14A
HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 GENECARDS:RPS6KB1 REACTOME:57803 KEGG:6198 ATLASONC:GC_RPS6KB1 WIKI:RPS6KB1

Maps_Modules
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:16286006
PMID:20647036
PMID:11108711

p70_alpha_*@Cytoplasm

References
s_mpk1_re264( Survival  map ):
PDK1 is a PI3K target leading to activation of P70 (through phosphorylation) and subsequent cell growth.
P70 activation requires both ERK cascade and PI3K/AKT cascade at least in some cell types.
PMID:12040186 PMID:11940578 PMID:10601235 PMID:11431469

p70_alpha_*|​pho@Cytoplasm

References
s_mpk1_re264( Survival  map ):
PDK1 is a PI3K target leading to activation of P70 (through phosphorylation) and subsequent cell growth.
P70 activation requires both ERK cascade and PI3K/AKT cascade at least in some cell types.
PMID:12040186 PMID:11940578 PMID:10601235 PMID:11431469
s_mpk1_re280( Survival  map ):
PDK1 is a PI3K target leading to activation of P70 and subsequent cell growth.
PMID:12040186

p70_alpha_*|​T389_pho|​T229_pho|​active@Cytoplasm

References
s_akt1_re68:( Survival  map ) PMID:16286006
s_akt1_re71( Survival  map ):
PMID:21233202
PMID:12713446
s_akt1_re73:( Survival  map ) PMID:17053147
s_akt1_re79( Survival  map ):
PMID:18423201
PMID:19339977
s_akt1_re86:( Survival  map ) PMID:19720745
s_akt1_re110:( Survival  map ) PMID:15905173
s_akt1_re114:( Survival  map ) PMID:17052453
s_akt1_re198:( Survival  map ) PMID:20832730

p70_alpha_*|​T389_pho@Cytoplasm

References
s_akt1_re66:( Survival  map ) PMID:16286006


Modifications:
In compartment: Cytoplasm
  1. p70_alpha_*@Cytoplasm map

  2. p70_alpha_*|​pho@Cytoplasm map
  3. p70_alpha_*|​T389_pho@Cytoplasm map
  4. p70_alpha_*|​T389_pho|​T229_pho|​active@Cytoplasm map

Participates in complexes:
In compartment: Cytoplasm

  1. EIF3*:​EIF4E*:​M7GTP*:​mRNA generic*:​p70_alpha_*@Cytoplasm map

  2. DEK:​REF*:​RNPS1:​SKAR*:​SRM160*:​Y14*:​p70_alpha_*|​T389_pho|​T229_pho@Cytoplasm map
  3. EIF3*:​EIF4E*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. (MTOR|​S1261_pho|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho)|​active@Cytoplasm map + EIF3*:​EIF4E*:​M7GTP*:​mRNA generic*:​p70_alpha_*@Cytoplasm map map EIF3*:​EIF4E*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm map

  2. EIF3*:​EIF4E*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*:​p70_alpha_*|​T389_pho@Cytoplasm map map EIF3*:​EIF4E*:​M7GTP*:​MTOR|​S1261_pho|​S2448_emp|​S2481_pho:​RPTOR|​S696_pho|​T706_pho|​S855_pho|​S863_pho|​S877_pho|​S859_pho:​mRNA generic*@Cytoplasm map + p70_alpha_*|​T389_pho@Cytoplasm map + 4E-BP*|​T37_pho|​T46_pho|​S65_pho|​T70_pho@Cytoplasm map
  3. p70_alpha_*|​T389_pho@Cytoplasm map map p70_alpha_*|​T389_pho|​T229_pho|​active@Cytoplasm map
  4. DEK:​REF*:​RNPS1:​SRM160*:​Y14*@Cytoplasm map + SKAR*@Cytoplasm map + p70_alpha_*|​T389_pho|​T229_pho|​active@Cytoplasm map map DEK:​REF*:​RNPS1:​SKAR*:​SRM160*:​Y14*:​p70_alpha_*|​T389_pho|​T229_pho@Cytoplasm map
  5. DEK:​REF*:​RNPS1:​SKAR*:​SRM160*:​Y14*:​p70_alpha_*|​T389_pho|​T229_pho@Cytoplasm map map mRNA translation@Cytoplasm map
  6. p70_alpha_*@Cytoplasm map map p70_alpha_*|​pho@Cytoplasm map
  7. p70_alpha_*|​pho@Cytoplasm map map Proliferation@Cytoplasm map

As Catalyser:

  1. MTOR@Cytoplasm map map MTOR|​S2448_pho@Cytoplasm map

  2. GSK3_beta_*@Cytoplasm map map GSK3_beta_*|​pho@Cytoplasm map
  3. s_s_akt1_s816 map s_s_akt1_s822
  4. EIF4B@Cytoplasm map map EIF4B|​S422_pho@Cytoplasm map
  5. RPS6|​S247_pho@Cytoplasm map map RPS6|​S235_pho|​S236_pho|​S240_pho|​S244_pho|​S247_pho@Cytoplasm map
  6. EIF4A*:​PDCD4@Cytoplasm map map EIF4A*:​PDCD4|​S67_pho@Cytoplasm map
  7. MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR@Lipid Raft map map MAPKAP1:​MLST8:​MTOR|​S2481_pho:​PROTOR*:​RAC1:​RICTOR|​T1135_pho@Lipid Raft map

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