p53*

Protein p53* map

Identifiers
tumor protein p53
HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / MOMP_REGULATION  map
 DNA repair  map  / G1_S_CHECKPOINT  map
 DNA repair  map  / G2_M_CHECKPOINT  map
 Cell cycle  map  / APOPTOSIS_ENTRY  map
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
PMID:21518799
p53 activates MIR200C
PMID:21483453
p53 activates microRNAs
PMID:21336307
p53 activates MIR34
PMID:17823410
PMID:6396087, PMID:21340684, PMID:20457558, PMID:20182602, PMID:20066118
P53 is a nuclear P38 target.
PMID:20506250
PMID:10721693
PMID:19459846

p53*@Nucleus

References
e_re9( EMT  map ):
PMID:19448627
Wild-type p53 inhibits Slug protein expression.
Slug protein levels were significantly decreased in parallel with increased wtp53 accumulation.
Slug mRNA levels did not change indicating that Slug is not transcriptionally regulated by wtp53
e_re366( EMT  map ):
PMID:19935649
SNAI1 inhibits miR-203
PMID:22514743
SNAI1 represses miR-203 and miR-200b expression
PMID:21159887
p53 activates expression of miR-203
PMID:20702634
PMID:20706219
Feedback loop: ZEB1 inhibits expression of MIR203 and MIR183
ZEB1 directly controls transcription of the miR-203 and miR-183 and miR-200 family genes
ZEB2 inhibits expression of MIR203
e_re427( EMT  map ):
PMID:12667443
p53 induces apoptosis by target gene regulation and transcription-independent signaling.
A fraction of induced p53 translocates to the mitochondria of apoptosing tumor cells. Targeting p53 to mitochondria is sufficient to launch apoptosis.
Evidence that p53 translocation to the mitochondria occurs in vivo in irradiatedthymocytes was shown.
Further, p53 can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BCL2L1, resulting in cytochrome c release.
p53 binds to BCL2L1 via its DNA binding domain.
Tumor-derived transactivation-deficient mutants of p53 concomitantly lose the ability to interact with BCL2L1 and promote cytochrome c release.
e_re721( EMT  map ):
PMID:18172008
p53 induces PTEN transcription
Snai1 inhibits gene expression
e_re1213( EMT  map ):
PMID:15140942
Phosphorylations on p53 prevent its binding to MDM2.
PMID:15574337
S186 phosphorylation of MDM2 by AKT favors the binding of MDM2 to p53 and its following degradation.
PMID:19336515
TWIST1 physically promotes interaction between p53 and MDM2
e_re1330:( EMT  map ) PMID:18049480

p53*@Mitochondria

References
e_re427( EMT  map ):
PMID:12667443
p53 induces apoptosis by target gene regulation and transcription-independent signaling.
A fraction of induced p53 translocates to the mitochondria of apoptosing tumor cells. Targeting p53 to mitochondria is sufficient to launch apoptosis.
Evidence that p53 translocation to the mitochondria occurs in vivo in irradiatedthymocytes was shown.
Further, p53 can directly induce permeabilization of the outer mitochondrial membrane by forming complexes with the protective BCL2L1, resulting in cytochrome c release.
p53 binds to BCL2L1 via its DNA binding domain.
Tumor-derived transactivation-deficient mutants of p53 concomitantly lose the ability to interact with BCL2L1 and promote cytochrome c release.
e_re434( EMT  map ):
PMID:14963330
Cytosolic localization of endogenous p53 was necessary and sufficient for apoptosis.
p53 directly activated the pro-apoptotic BCL2 protein Bax in the absence of other proteins to permeabilize mitochondria and engage the apoptotic program.
e_re437( EMT  map ):
PMID:15077116
p53 has a direct signalling role at mitochondria in the induction of apoptosis
p53 interacts with the pro- apoptotic mitochondrial membrane protein Bak. Interaction of p53 with Bak causes oligomerization and thus activation of Bak and release of cytochrome c from mitochondria.
Formation of the p53–Bak complex coincides with loss of an interaction between Bak and the anti-apoptotic Bcl2-family member Mcl1.
These results are consistent with a model in which p53 and Mcl1 have opposing effects on mitochondrial apoptosis by interacting with, and modulating the activity of, the death effector Bak.

p53*|​S15_unk@Cytoplasm

References
a_re1406( Apoptosis  map ):
PMID:18845789
unphosphorylated TP53 from coIP experiments with okadaic acid (PKC inhibitor) or ceramide C2 (potent inductor of PP1/2A

p53*@Cytoplasm

References
a_re210( Apoptosis  map ):
PMID:19293287
in SH-SY5Y human neuroblastoma cell line
in Swiss-3T3 mouse fibroblast cell line
in primary human lung fibroblasts
in H1299 human non-small cell lung carcinoma cell line (p53 null) with ectopic expression of p53, identification of the miRNA site in the UTR

p53*|​S15_pho|​active@Nucleus

References
a_re98( Apoptosis  map ):
PMID:18056423
p53 mediated upregulation of IGFBP1
in mouse liver
PMID:9707622
in HepG2, by HIF1
PMID:10102273
in 293T, by FOXO3, EMSA
a_re106( Apoptosis  map ):
PMID:18208354
TP53 downregulates the activity of the MCL1 gene promoter in Hela and HEK293
mainly through an unkown mechanism. Critical importance of the -41 to +16 region that correspond to TATA-BP and other basal transcription factors binding
also through down regulation of Sp1
PMID:19808698
in MV4-11 cells, a human biphenotypic B myelomonocytic leukemia that displays FLT3-ITD mutation (constitutive FLT3 signalling), STAT5* siRNA prevents MCL1 expression
PMID:11160159
in large granular lymphocyte high STAT3 activity correlates with MCL1 expression, AG-490 JAK inhibitors induce apoptosis and decreases MCL1 expression.
in NIH3T3, upon v-src, STAT3 dependent expression of MCL1
a_re108:( Apoptosis  map ) PMID:17409411
a_re115( Apoptosis  map ):
PMID:7566179
in EB1 colon carninoma cells expressing p53 under the control of an inducible promoter
in Saos-2 huamn osteosarcoma cells expressing a temperature sensitive p53
PMID:17409411
in mouse spleen and thymus upon irradiation
a_re118( Apoptosis  map ):
PMID:18692468
PMID:9926927
a_re119( Apoptosis  map ):
PMID:12203114
a_re124:( Apoptosis  map ) PMID:19203586
a_re126( Apoptosis  map ):
PMID:14699081
in Saos-2, direct transactivation of NOXA by HIF1A during hypoxia, role of NOXA in hypoxia-induced cell death
PMID:16888645
in SH-EP, in NB15 neuroblastoma cell lines expressing a FOXO3-ER fusion, upon 4OHT. PMAIP knock down protects from apoptosis
PMID:12676992
in MEF by CTBP1 and CTBP2 (RT-PCR, double knocked out)
PMID:14684737
in NIH3T3, by E2F1
a_re127( Apoptosis  map ):
PMID:11463391
by p53
PMID:11463392
PMID:14634023
in Saos-2, by p73
in NIH3T3 and in Saos-2, by E2F1
a_re130( Apoptosis  map ):
PMID:12402042
in mouse splenic red pulp and colonic epithelium, upon irradiation
in human, the p53 binding element is conserved
PMID:15024076
in HT29 and CHO, HIF1-dependent hypoxia-induced repression of BID expression
in SW480 upon hypoxia, interaction between HIF1 and BID promoter, by EMSA
PMID:15240700
in mouse T cells, by E2F1
a_re131( Apoptosis  map ):
PMID:19211844
FOXO3 mediated inhibition
PMID:11714700
TP53 mediated inhibition
PMID:11965534
a_re133:( Apoptosis  map ) PMID:17000778
a_re134( Apoptosis  map ):
PMID:7834749
PMID:15613549
in HEK 293, by NFkB, upon expression of LMP1 protein (from EBV). More precisely, p65/p50 dimer inhibits BAX promoter activity whereas p50/p50 dimer is actually an transcriptional activator or BAX. However p65 has to be inhibited to see p50/p50 mediated activation of BAX
in MEF double knocked out by CTBP1 and CTBP2 (RT-PCR)
a_re136( Apoptosis  map ):
PMID:8242752
by TP53
a_re137:( Apoptosis  map ) PMID:16728594
a_re139( Apoptosis  map ):
PMID:11389439
PMID:11591730
PMID:11559530
a_re140:( Apoptosis  map ) PMID:16839880
a_re141( Apoptosis  map ):
PMID:17554199
PMID:17656095
PMID:17540599
PMID:17554337
PMID:19696787
in TIG3 TERT/ΔB-RAF:ER, by ELK1 (siRNA ELK1 and MIR34A PCR; ChIP)
in HEK293 by ELK1, gene reporter
a_re142( Apoptosis  map ):
PMID:14985507
mouse homolog siah-1b is a direct target of p53
PMID:12077306
sequence analysis predicts SIAH1 as a p53 target gene
PMID:12438652
in human colorectal carcinoma-derived cell lines with a somatic knock-out of p53 (p53 +/+, p53 +/−, and p53 −/−), SIAH1 expression correlates with that of p53
a_re146( Apoptosis  map ):
PMID:18328430
MIR17HG transactivation by E2F1
PMID:15944709
MIR17-92 cluster transactivation by MYC
PMID:19696742
MIR17HG transactivation repressed by TP53. Proposed mechanism: TP53- and TBP- binding sites overlaps.
in human colorectal carcinoma HCT116 (TP53 competent cells), MIR17HG repression upon hypoxia and TP53 stabilization.
in human colorectal carcinoma cells HCT116 and LOVO, this effect is blocked by siRNA against TP53
in HCT116 and LOVO, siRNA against MYC represses MIR17-92 expression
a_re174( Apoptosis  map ):
PMID:7493931
in HepG2 by HIF1 (EMSA, reporter plasmids)
PMID:9525945
in chinese hamster ovary cells by HIF1
PMID:15059920
in Saos2, in human embryonal rhabdomyosarcoma derived RD (ATCC no. CCL-136), in murine skeletal muscle-derived C2C12 myoblasts (ATCC no. CRL-1772), by TP53 (luciferase reporter)
a_re215( Apoptosis  map ):
PMID:11704864
in LNCaP human prostate cancer cell line
PMID:11313951
transrepression by p53
a_re381:( Apoptosis  map ) PMID:15105421
a_re784:( Apoptosis  map ) PMID:10716435
a_re1127( Apoptosis  map ):
PMID:19590512
Siva1 and mdm2
PMID:15989956
HUWE1
PMID:19960022
effect of SIRT1 K382-deacetylation
a_re1198( Apoptosis  map ):
PMID:20308559
in Hela cells
in HCT116 wt, but not in p53-deficient conterpart, etoposide induces the expression of PANK1 and MIR107, + luciferase reporter and ChIP assays
a_re1222:( Apoptosis  map ) PMID:20378837
a_re1229( Apoptosis  map ):
in Saos2, in human embryonal rhabdomyosarcoma derived RD (ATCC no. CCL-136), in murine skeletal muscle-derived C2C12 myoblasts (ATCC no. CRL-1772), by TP53 (luciferase reporter) upon transfection, but not by mutant TP53
in vitro binding of in vitro translated TP53 to the promoter
a_re1235:( Apoptosis  map ) PMID:16839881
a_re1403( Apoptosis  map ):
PMID:15073321
PMID:10973264

p53*|​pho|​ace|​active@default

References
d_re34:( DNA repair  map ) PMID:19788416
d_re226( DNA repair  map ):
BRCA1 up-regulates transcription of GADD45 in p53 independed manner:
PMID:10367887, PMID:10962562
PMID:19004803, PMID:12496474
p53 enhances transcription of GADD45:
PMID:9892649, PMID:10779360
p53 regulated global genomic NER at the level of DNA damage recognition involving GADD45, XPC, DDB2:
PMID:12771027, PMID:9346961
d_re228( DNA repair  map ):
BRCA1 enhances transcription of DDB2 in p53 independent manner
PMID:19004803, PMID:12496474, PMID:12170778
p53 enhances transcription of DDB2:
d_re231( DNA repair  map ):
BRCA1 upregulates transcription of XPC in p53 independed manner:
p53 enhances transcription of XPC:
d_re344:( DNA repair  map ) CHECKPOINT is p53_dependent_G1S_checkpoint

p53*@default

References
d_re34:( DNA repair  map ) PMID:19788416
d_re48( DNA repair  map ):
BRCA1 stabilises p53 and causes activation of p53-dependent DNA-repair genes and activation of checkpoint, but no apoptoss:
PMID:12024039 , PMID:12496474

p53*|​Ser15_pho|​Ser20_pho@Nucleus

References
c_re135:( Cell cycle  map ) PMID:15024084, PMID:15140942

p53*|​Ser15_pho@Nucleus

References
c_re132( Cell cycle  map ):
PMID:15024084
ATM phosphorylates p53 in case of DNA double-strand breaks. ATR phosphorylates p53 in case of other types of DNA damages.
PMID:15140942
E2F1 stimulates ATM to phosphorylate p53 (and Chk2)
PMID:15140942, PMID:9843217, PMID:9733515, PMID:9733514
c_re135:( Cell cycle  map ) PMID:15024084, PMID:15140942

p53*|​ubi@Nucleus

References
s_akt2_re70( Survival  map ):
PMID:10721693
PMID:19459846

p53*|​ubi|​ubi@Nucleus

References
s_akt2_re77( Survival  map ):
PMID:10721693
PMID:19459846


Modifications:
In compartment: Cytoplasm
  1. p53*@Cytoplasm map

  2. p53*|​ubi@Cytoplasm map
  3. p53*|​S15_unk@Cytoplasm map

In compartment: Mitochondria

  1. p53*@Mitochondria map

In compartment: Nucleus

  1. p53*@Nucleus map

  2. p53*|​pho@Nucleus map
  3. p53*|​ubi@Nucleus map
  4. p53*|​Ser15_pho@Nucleus map
  5. p53*|​ubi|​ubi@Nucleus map
  6. p53*|​S15_pho|​active@Nucleus map
  7. p53*|​Ser15_pho|​Ser20_pho@Nucleus map

In compartment: default

  1. p53*@default map

  2. p53*|​pho|​ace|​active@default map

Participates in complexes:
In compartment: Cytoplasm

  1. BAX:​p53*@Cytoplasm map

  2. MDM2|​S186_pho:​p53*@Cytoplasm map

In compartment: Mitochondria

  1. BAK1:​p53*@Mitochondria map

  2. BCL2:​p53*@Mitochondria map
  3. BCL2-XL*:​p53*@Mitochondria map

In compartment: Mitochondrial outer membrane

  1. BCL2:​p53*@Mitochondrial outer membrane map

  2. BCL2-XL*:​p53*@Mitochondrial outer membrane map

In compartment: Nucleus

  1. NICD*:​p53*@Nucleus map

  2. MDM2|​S186_pho:​p53*@Nucleus map
  3. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map
  4. MDM2|​S186_pho:​SNAI2:​p53*@Nucleus map

In compartment: default

  1. PARP1:​p53*@default map

Participates in reactions:
As Reactant or Product:

  1. p53*|​S15_pho|​active@Nucleus map map p53*@Nucleus map

  2. p53*@Nucleus map map p53*|​S15_pho|​active@Nucleus map
  3. BCL2|​unk@Mitochondrial outer membrane map + p53*|​S15_unk@Cytoplasm map map BCL2:​p53*@Mitochondrial outer membrane map
  4. BCL2-XL*@Mitochondrial outer membrane map + p53*|​S15_unk@Cytoplasm map map BCL2-XL*:​p53*@Mitochondrial outer membrane map
  5. p53*@Cytoplasm map map p53*@Nucleus map
  6. rp53*@Nucleus map map p53*@Cytoplasm map
  7. p53*@Nucleus map map p53*|​Ser15_pho@Nucleus map
  8. p53*|​Ser15_pho@Nucleus map map p53*|​Ser15_pho|​Ser20_pho@Nucleus map
  9. MDM2@Nucleus map + p53*@Nucleus map map c_s731
  10. p53*@Cytoplasm map map degraded
  11. c_s1127 map p53*@Cytoplasm map + MDM2@Cytoplasm map
  12. p53*@default map map p53*|​pho|​ace|​active@default map
  13. p53*@default map + PARP1|​PolyADPribose_unk|​pho@Nucleus map map PARP1:​p53*@default map
  14. p53*@default map map degraded
  15. p53*@Nucleus map map p53*|​pho@Nucleus map
  16. p53*@Nucleus map + MDM2|​S186_pho@Nucleus map map MDM2|​S186_pho:​p53*@Nucleus map
  17. MDM2|​S186_pho:​p53*@Nucleus map map MDM2|​S186_pho:​p53*@Cytoplasm map
  18. MDM2|​S186_pho:​p53*@Cytoplasm map map degraded
  19. SNAI2@Nucleus map + MDM2|​S186_pho:​p53*@Nucleus map map MDM2|​S186_pho:​SNAI2:​p53*@Nucleus map
  20. MDM2|​S186_pho:​SNAI2:​p53*@Nucleus map map degraded
  21. p53*@Nucleus map + NICD*@Nucleus map map NICD*:​p53*@Nucleus map
  22. MDM2|​S186_pho:​p53*@Nucleus map map degraded
  23. BCL2-XL*@Mitochondria map + p53*@Mitochondria map map BCL2-XL*:​p53*@Mitochondria map
  24. p53*@Nucleus map map p53*@Mitochondria map
  25. p53*@Mitochondria map + BCL2@Mitochondria map map BCL2:​p53*@Mitochondria map
  26. p53*@Mitochondria map + BAX@Cytoplasm map map BAX:​p53*@Cytoplasm map
  27. BAX:​p53*@Cytoplasm map map Apoptosis@Cytoplasm map
  28. p53*@Mitochondria map + BAK1@Mitochondria map map BAK1:​p53*@Mitochondria map
  29. BAK1:​p53*@Mitochondria map map Apoptosis@Cytoplasm map
  30. p53*@Nucleus map map p53*|​ubi@Nucleus map
  31. p53*|​ubi@Nucleus map map p53*|​ubi@Cytoplasm map
  32. p53*@Nucleus map map p53*|​ubi|​ubi@Nucleus map
  33. p53*@Nucleus map map p53*|​pho@Nucleus map
  34. p53*|​pho@Nucleus map map gGADD45*@Nucleus map
  35. p53*|​pho@Nucleus map map gp21CIP1*@Nucleus map
  36. p53*|​pho@Nucleus map map gPERP@Nucleus map
  37. p53*|​pho@Nucleus map map gMDM2@Nucleus map
  38. p53*|​pho@Nucleus map map gPMAIP1@Nucleus map
  39. p53*|​pho@Nucleus map map gDDB2@Nucleus map
  40. p53*|​pho@Nucleus map map p53*@Nucleus map
  41. p53*|​pho@Nucleus map map Apoptosis@Cytoplasm map
  42. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map map Apoptosis@Nucleus map
  43. AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map map p53-target genes@Nucleus map
  44. AXIN*@Nucleus map + p53*@Nucleus map + HIPK2@Nucleus map map AXIN*:​HIPK2@Nucleus map
  45. AXIN*:​HIPK2@Nucleus map map AXIN*:​HIPK2:​p53*|​S46_pho@Nucleus map

As Catalyser:

  1. gPKA_R*@Nucleus map map rPKA_R*@Nucleus map

  2. gMCL1@Nucleus map map rMCL1@Nucleus map
  3. gPTEN@Nucleus map map rPTEN@Nucleus map
  4. gTSC2@Nucleus map map rTSC2@Nucleus map
  5. gIGFBP3@Nucleus map map rIGFBP3@Nucleus map
  6. gSESN1@Nucleus map map rSESN1@Nucleus map
  7. gSESN2@Nucleus map map rSESN2@Nucleus map
  8. gPANK1@Nucleus map map rpre-mRNA~PANK1*@Nucleus map
  9. gGLS2@Nucleus map map rGLS2@Nucleus map
  10. gSLC2A4@Nucleus map map rSLC2A4@Nucleus map
  11. gDRAM1@Nucleus map map rDRAM1@Nucleus map
  12. gPHLDA3@Nucleus map map rPHLDA3@Nucleus map
  13. gPMAIP1@Nucleus map map rPMAIP1@Nucleus map
  14. gBBC3@Nucleus map map rBBC3@Nucleus map
  15. gPYCARD@Nucleus map map rPYCARD@Nucleus map
  16. gBID@Nucleus map map rBID@Nucleus map
  17. gBIRC5@Nucleus map map rBIRC5@Nucleus map
  18. gBAD@Nucleus map map rBAD@Nucleus map
  19. gBAX@Nucleus map map rBAX@Nucleus map
  20. gp21CIP1*@Nucleus map map rp21CIP1*@Nucleus map
  21. gSCO2@Nucleus map map rSCO2@Nucleus map
  22. gAPAF1@Nucleus map map rAPAF1@Nucleus map
  23. gTIGAR*@Nucleus map map rTIGAR*@Nucleus map
  24. gLRDD@Nucleus map map rLRDD@Nucleus map
  25. gMIR34A@Nucleus map map arMIR34A@Cytoplasm map
  26. gSIAH1@Nucleus map map rSIAH1@Nucleus map
  27. gMIR17-92*@Nucleus map map arMIR17-92*@Nucleus map
  28. gSLC2A1@Nucleus map map rSLC2A1@Nucleus map
  29. gBCL2@Nucleus map map rBCL2@Nucleus map
  30. gSIVA1@Nucleus map map rSIVA1@Nucleus map
  31. gRRM2B@Nucleus map map rRRM2B@Nucleus map
  32. gIGFBP1@Nucleus map map rIGFBP1@Nucleus map
  33. G1 phase@default map map S phase@default map
  34. gGADD45*@default map map rGADD45*@default map
  35. gDDB2@default map map rDDB2@default map
  36. gXPC@default map map rXPC@default map
  37. gCIP/KIP*@default map map rCIP/KIP*@default map
  38. MAX@default map + MYC@default map map MAX:​MYC@default map
  39. g14-3-3*@default map map r14-3-3*@default map
  40. gMIR203@Nucleus map map arMIR203@Nucleus map
  41. gPTEN@Nucleus map map rPTEN@Nucleus map
  42. rSNAI2@Nucleus map map SNAI2@Nucleus map
  43. gMDM2@Nucleus map map rMDM2@Nucleus map
  44. gMIR34A@Nucleus map map arMIR34A@Nucleus map
  45. gMIR34B@Nucleus map map arMIR34B@Nucleus map
  46. gMIR34C@Nucleus map map arMIR34C@Nucleus map

Leave a Reply