p38*

Protein p38* map

Identifiers
mitogen-activated protein kinase 11
HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11
mitogen-activated protein kinase 12
HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12
mitogen-activated protein kinase 13
HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13
mitogen-activated protein kinase 14
HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14
PRKM11
SAPK3
PRKM13
CSBP1 CSBP2 CSPB1
Mxi2 P38 “P38 MAP kinase” PRKM14 PRKM15

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / CASPASES  map
 Apoptosis  map  / TNF_RESPONSE  map
 Survival  map  / MAPK  map
 Survival  map  / WNT_CANONICAL  map
 Survival  map  / WNT_NON_CANONICAL  map

References
synonym:p38_beta_
synonym:p38_gamma_
synonym:p38_delta_
synonym:p38

p38*@Nucleus

References
e_re1186( EMT  map ):
PMID:21502402
Phosphorylation of serine 68 of Twist1 stabilizes Twist1 protein and promotes breast cancer cell invasiveness.
Twist1 can be phosphorylated in vitro at Serin 68 by MAPKs (p38MAPKs, JNKs, ERK1/2)
This phosphorylation is required for Twist1 protein stability.
pSer 68 stabilizes Twist1 by protecting Twist1 from ubiquitination
Ser 68 phosphorylation is required for Twist1- promoted EMT and breast cancer cell invasion

p38*|​T180_pho|​Y182_pho@Cytoplasm

References
a_re498( Apoptosis  map ):
PMID:12792650
Direct phosphorylation of CASP9 by ERK2 sufficient to block CASP9 processing
in vitro, recombinant hCASP9 phosphorylated on T125 by cytosolic extract or ERK2
in Hela cells, interaction GST-CASP9 / ERK
in Hela or HEK293, CASP9 T125 phosphorylation by OA, consititutively active MEK1, EGF or TPA
PMID:17466630
CASP9 T125 phosphorylation by CCNB1:CDC2
comment: phosphorylation during mitosis, when nuclear envelope is broken down
PMID:19081073
CASP9 T125 phosphorylation by DYRK1A
PMID:19016842
PMID:19586613
CASP9 T125 phosphorylation by DYRK1A and p38
a_re1323( Apoptosis  map ):
PMID:11359773
by DUSP16

p38*@Cytoplasm

References
a_re1318:( Apoptosis  map ) reactionType:is.a
a_re1323( Apoptosis  map ):
PMID:11359773
by DUSP16

p38*|​pho|​pho@Cytoplasm

References
s_mpk1_re155( Survival  map ):
MEK3 and MEK6 are high selective for P38 activation (by phosphorylation).
PMID:11274345
s_mpk1_re163( Survival  map ):
MAPKAPK2 and MAPKAPK3 are phosphorylated and activated by P38alpha and P38 beta.
s_mpk1_re165( Survival  map ):
MNKs are cytoplasmic targets of ERK and P38.
PMID:15187187
s_mpk1_re166( Survival  map ):
MAX is phosphorylated by P38 through complex formation (not represented here).
s_mpk1_re182:( Survival  map ) Nuclear shuttling of activated P38 is assumed similarly to ERK.
s_mpk1_re187( Survival  map ):
JNK pathway negatively regulates ERK pathway by uncoupling ERK activation from MEK via activation of JUN transcriptional activity.
A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:12738796 PMID:18039929
s_mpk1_re189( Survival  map ):
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation.
PMID:18039929
s_mpk1_re194( Survival  map ):
MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex.
s_s_mpk1_re163( Survival  map ):
s_s_mpk1_re166( Survival  map ):
s_s_mpk1_re194( Survival  map ):

p38*|​pho|​pho@Nucleus

References
s_mpk1_re182:( Survival  map ) Nuclear shuttling of activated P38 is assumed similarly to ERK.
s_mpk1_re91( Survival  map ):
The rapid and efficient phosphorylation of Elk1 by ERKs is enabled by a direct interaction between the two proteins.
ELK1 is a nuclear P38 target.
ELK1 is a nuclear JNK target.
PMID:16393692 PMID:20506250 PMID:11274345
s_mpk1_re95( Survival  map ):
MSK1 and MSK2 are potently activated (by phosphorylation) in vivo by ERK1/2 and P38 but not JNK. They are localised in the nucleus of quiescent and activated cells which suggest that they may preferentially phosphorylate nuclear substrates.
PMID:15187187
s_mpk1_re168( Survival  map ):
P38 and not JNK or ERK can phosphorylate CHOP/GADD153 (DDIT3).
PMID:11274345
s_mpk1_re176( Survival  map ):
ATF2 is a nuclear P38 target.
ATF2 is a nuclear JNK target.
PMID:20506250 PMID:11274345
s_mpk1_re179( Survival  map ):
P53 is a nuclear P38 target.
Activated P38 phosphorylates P53 at several residues including Ser33 and thereby increases the transcriptional activity of P53.
ATM phosphorylates P53 at ser15 and stabilize it.
PMID:20506250 PMID:21614932 PMID:15140942
s_mpk1_re181( Survival  map ):
MKP-1 (DUSP1) preferentially inactivates JNK and P38.
PMID:19436832


Modifications:
In compartment: Cytoplasm
  1. p38*@Cytoplasm map

  2. p38*|​pho|​pho@Cytoplasm map
  3. p38*|​T180_pho|​Y182_pho@Cytoplasm map

In compartment: Nucleus

  1. p38*@Nucleus map

  2. p38*|​pho|​pho@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. DUSP1:​p38*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. MAPK14@Cytoplasm map map p38*@Cytoplasm map

  2. MAPK11@Cytoplasm map map p38*@Cytoplasm map
  3. MAPK13@Cytoplasm map map p38*@Cytoplasm map
  4. MAPK12@Cytoplasm map map p38*@Cytoplasm map
  5. p38*@Cytoplasm map map p38*|​T180_pho|​Y182_pho@Cytoplasm map
  6. p38*|​T180_pho|​Y182_pho@Cytoplasm map map p38*@Cytoplasm map
  7. p38*@Nucleus map map MAPK11@Nucleus map
  8. p38*@Nucleus map map MAPK12@Nucleus map
  9. p38*@Nucleus map map MAPK13@Nucleus map
  10. p38*@Nucleus map map MAPK14@Nucleus map
  11. p38*@Cytoplasm map map p38*|​pho|​pho@Cytoplasm map
  12. DUSP1@Nucleus map + p38*|​pho|​pho@Nucleus map map DUSP1:​p38*@Nucleus map
  13. p38*|​pho|​pho@Cytoplasm map map p38*|​pho|​pho@Nucleus map
  14. p38*@Cytoplasm map map s_s_wca3_s794
  15. ASK1*@Cytoplasm map map p38*@Cytoplasm map
  16. p38*@Cytoplasm map map Apoptosis@Mitochondria map
  17. p38*@Cytoplasm map map MAPK pathway@Cytoplasm map
  18. MAPK pathway@Cytoplasm map map p38*@Nucleus map

As Catalyser:

  1. Caspase9*|​S196_unk|​S144_unk|​Y153_unk@Cytoplasm map map Caspase9*|​S196_unk|​T125_pho|​S144_unk|​Y153_unk@Cytoplasm map

  2. TWIST1@Nucleus map map TWIST1|​S68_pho@Nucleus map
  3. MAPKAPK*@Cytoplasm map map MAPKAPK*|​pho@Cytoplasm map
  4. MNK*@Cytoplasm map map MNK*|​pho@Cytoplasm map
  5. MAX@Cytoplasm map map MAX|​pho@Cytoplasm map
  6. DDIT3@Nucleus map map DDIT3|​pho@Nucleus map
  7. ATF2@Nucleus map map ATF2|​pho@Nucleus map
  8. p53*@Nucleus map map p53*|​pho@Nucleus map
  9. ERK*|​pho|​pho@Cytoplasm map map ERK*@Cytoplasm map
  10. ERK*|​pho|​pho:​KSR1:​MEK*|​pho|​pho@Cytoplasm map map KSR1:​MEK*@Cytoplasm map + ERK*@Cytoplasm map
  11. ERK*|​pho|​pho:​MEK*|​pho|​pho:​SEF*@Cytoplasm map map MEK*:​SEF*@Cytoplasm map + ERK*@Cytoplasm map
  12. ERK*|​pho|​pho:​MEK*|​pho|​pho:​_beta_-Arrestin2*@Early Endosomes map map MEK*:​_beta_-Arrestin2*@Cytoplasm map + ERK*@Cytoplasm map
  13. ERK*|​pho|​pho:​GRB2:​LAMTOR2:​MEK*|​pho|​pho:​MP1*:​RAF1|​pho:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map map GRB2:​LAMTOR2:​MEK*:​MP1*:​RAS*|​pho:​RTK*:​SOS*@Late Endosomes map + ERK*@Cytoplasm map + RAF1@Cytoplasm map
  14. PP2A_C*@Cytoplasm map map PP2A_C*|​unk@Cytoplasm map
  15. ERK*|​pho|​pho@Cytoplasm map map ERK*|​pho|​pho@Nucleus map
  16. ELK1@Nucleus map map ELK1|​pho@Nucleus map
  17. MSK*@Nucleus map map MSK*|​pho@Nucleus map
  18. s_s_s4327 map s_s_s4327
  19. (NFAT*:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map map (NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho:​PPP3CB_sub_trunc_endsub_*:​PPP3R*)|​active@Cytoplasm map
  20. gNFAT1_2*@Nucleus map map rNFAT1_2*@Nucleus map

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