p27KIP1*

Protein p27KIP1* map

Identifiers
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 Cell cycle  map  / CYCLINA  map
 Cell cycle  map  / CYCLINE  map
 Cell cycle  map  / P27KIP  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:18636226
PMID:19887899

p27KIP1*@Nucleus

References
a_re409( Apoptosis  map ):
PMID:18521080
in human hepatocellular carcinoma
a_re1130:( Apoptosis  map ) cf. Rb pathway
a_re1132:( Apoptosis  map ) PMID:18593906

p27KIP1*|​T198_pho|​T157_pho@Nucleus

References
a_re1132:( Apoptosis  map ) PMID:18593906
a_re1133( Apoptosis  map ):
PMID:18593906
in HEK293T with transfected proteins

p27KIP1*|​Thr157_pho@Cytoplasm

References
c_re270( Cell cycle  map ):
Phosphorylation of p27 at Thr-157 in its NLS, which impair its nuclear import.
PMID:12851486, PMID:9632134

p27KIP1*|​Thr157_pho@Nucleus

References
c_re269( Cell cycle  map ):
Phosphorylation of p27 at Thr-157 by AKT-1 induce its cytoplasmic localization.
PMID:12851486
c_re270( Cell cycle  map ):
Phosphorylation of p27 at Thr-157 in its NLS, which impair its nuclear import.
PMID:12851486, PMID:9632134

p27KIP1*|​Thr187_pho@Nucleus

References
c_re169( Cell cycle  map ):
Phosphorylation of p27 by cyclin E/CDK2 at Thr-187 results in targeting p27 for its degradation by proteolysis
PMID:10385618
c_re196( Cell cycle  map ):
Proteolysis degradation via the SCF(SKP2) system.
PMID:10385618, PMID:12814430, PMID:12851486
Preliminary phosphorylation and cytoplasm export needed for degradation.
PMID:11355576

p27KIP1*|​S10_pho@Cytoplasm

References
s_akt1_re96( Survival  map ):
PMID:18570873
PMID:18636226
p27 is phosphorylated by Akt RSK1 and RSK2 in early G1 phase

p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm

References
s_akt1_re96( Survival  map ):
PMID:18570873
PMID:18636226
p27 is phosphorylated by Akt RSK1 and RSK2 in early G1 phase
s_akt1_re97:( Survival  map ) PMID:19887899

p27KIP1*|​pho@Nucleus

References
s_akt2_re38( Survival  map ):
PMID:18636226
PMID:15147722
PMID:14536078
PMID:12459251
s_akt2_re39:( Survival  map ) PMID:15147722 PMID:18006823

p27KIP1*|​pho|​pho@Nucleus

References
s_akt2_re39:( Survival  map ) PMID:15147722 PMID:18006823

p27KIP1*|​pho|​pho|​emp|​ubi|​ubi|​ubi@Cytoplasm

References
s_akt2_re48:( Survival  map ) PMID:15147722

p27KIP1*|​pho|​ubi|​ubi|​ubi@Cytoplasm

References
s_akt2_re46:( Survival  map ) PMID:15531880

p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus

References
s_akt2_re137:( Survival  map ) PMID:11124803
s_akt2_re140:( Survival  map ) PMID:18006823

p27KIP1*|​pho|​pho|​ubi|​pho|​S157_pho@Nucleus

References
s_akt2_re140:( Survival  map ) PMID:18006823


Modifications:
In compartment: Cytoplasm
  1. p27KIP1*@Cytoplasm map

  2. p27KIP1*|​pho@Cytoplasm map
  3. p27KIP1*|​S10_pho@Cytoplasm map
  4. p27KIP1*|​Thr157_pho@Cytoplasm map
  5. p27KIP1*|​pho|​ubi|​ubi|​ubi@Cytoplasm map
  6. p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm map
  7. p27KIP1*|​pho|​pho|​emp|​ubi|​ubi|​ubi@Cytoplasm map

In compartment: Nucleus

  1. p27KIP1*@Nucleus map

  2. p27KIP1*|​pho@Nucleus map
  3. p27KIP1*|​Thr157_pho@Nucleus map
  4. p27KIP1*|​Thr187_pho@Nucleus map
  5. p27KIP1*|​pho|​pho@Nucleus map
  6. p27KIP1*|​T198_pho|​T157_pho@Nucleus map
  7. p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus map
  8. p27KIP1*|​pho|​pho|​ubi|​pho|​S157_pho@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. CRM1*:​p27KIP1*|​pho@Cytoplasm map

  2. 14-3-3*|​unk:​p27KIP1*|​T198_pho|​T157_pho@Cytoplasm map
  3. CDK4_6*:​CyclinD1*:​p27KIP1*@Cytoplasm map

In compartment: Nucleus

  1. CRM1*:​p27KIP1*|​pho@Nucleus map

  2. CDK4_6*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Nucleus map
  3. (CDK4_6*:​p27KIP1*|​pho|​pho|​pho|​S157_pho)|​active@Nucleus map
  4. CDK2:​CyclinA*:​p27KIP1*@Nucleus map
  5. CDK2:​CyclinE*:​p27KIP1*@Nucleus map
  6. CDK4:​CyclinD*:​p27KIP1*@Nucleus map
  7. CDK6:​CyclinD*:​p27KIP1*@Nucleus map
  8. CDK6|​Thr_pho:​CyclinD*:​p27KIP1*@Nucleus map
  9. CDK4|​Thr172_pho:​CyclinD*:​p27KIP1*@Nucleus map
  10. CDK4_6*:​CyclinD*|​T286_pho:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. p27KIP1*@Nucleus map map p27KIP1*|​T198_pho|​T157_pho@Nucleus map

  2. 14-3-3*|​unk@Cytoplasm map + p27KIP1*|​T198_pho|​T157_pho@Nucleus map map 14-3-3*|​unk:​p27KIP1*|​T198_pho|​T157_pho@Cytoplasm map
  3. rp27KIP1*@Nucleus map map p27KIP1*@Nucleus map
  4. p27KIP1*@Nucleus map map p27KIP1*|​Thr187_pho@Nucleus map
  5. CDK2:​CyclinE*@Nucleus map + p27KIP1*@Nucleus map map CDK2:​CyclinE*:​p27KIP1*@Nucleus map
  6. CDK2:​CyclinA*@Nucleus map + p27KIP1*@Nucleus map map CDK2:​CyclinA*:​p27KIP1*@Nucleus map
  7. CDK6:​CyclinD*:​p27KIP1*@Nucleus map map CDK6|​Thr_pho:​CyclinD*:​p27KIP1*@Nucleus map
  8. CDK4:​CyclinD*:​p27KIP1*@Nucleus map map CDK4|​Thr172_pho:​CyclinD*:​p27KIP1*@Nucleus map
  9. p27KIP1*@Nucleus map + CDK4:​CyclinD*@Nucleus map map CDK4:​CyclinD*:​p27KIP1*@Nucleus map
  10. p27KIP1*@Nucleus map + CDK6:​CyclinD*@Nucleus map map CDK6:​CyclinD*:​p27KIP1*@Nucleus map
  11. p27KIP1*|​Thr187_pho@Nucleus map map degraded
  12. p27KIP1*@Nucleus map map p27KIP1*|​Thr157_pho@Nucleus map
  13. p27KIP1*|​Thr157_pho@Nucleus map map p27KIP1*|​Thr157_pho@Cytoplasm map
  14. p27KIP1*@Cytoplasm map map p27KIP1*|​pho@Cytoplasm map
  15. p27KIP1*|​pho@Cytoplasm map map degraded
  16. rp27KIP1*@Nucleus map map p27KIP1*@Cytoplasm map
  17. CDK4_6*:​CyclinD1*@Cytoplasm map + p27KIP1*@Cytoplasm map map CDK4_6*:​CyclinD1*:​p27KIP1*@Cytoplasm map
  18. rp27KIP1*@Nucleus map map p27KIP1*@Cytoplasm map
  19. s_s_akt1_s467 map CDK4_6*:​p27KIP1*|​S10_pho|​T187_pho|​pho@Nucleus map
  20. p27KIP1*|​S10_pho@Cytoplasm map map p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm map
  21. p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm map + 14-3-3*@Cytoplasm map map s_s_akt1_s462
  22. CDK4_6*@Cytoplasm map + p27KIP1*|​S10_pho|​T187_emp|​pho|​pho@Cytoplasm map + c_s761 map s_s_akt1_s467
  23. (CDK4_6*:​p27KIP1*|​pho|​pho|​pho|​S157_pho)|​active@Nucleus map map CDK4_6*:​CyclinD*|​T286_pho:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus map
  24. CDK4_6*:​CyclinD*|​T286_pho:​p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus map map CyclinD*|​T286_pho@Nucleus map + p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus map + CDK4_6*@Nucleus map
  25. p27KIP1*|​pho|​pho|​pho|​S157_pho@Nucleus map map p27KIP1*|​pho|​pho|​ubi|​pho|​S157_pho@Nucleus map
  26. rp27KIP1*@Nucleus map map p27KIP1*@Cytoplasm map
  27. p27KIP1*@Nucleus map map p27KIP1*|​pho@Nucleus map
  28. p27KIP1*|​pho@Nucleus map map p27KIP1*|​pho|​pho@Nucleus map
  29. p27KIP1*|​pho|​pho@Nucleus map map G0 phase@Nucleus map
  30. CyclinE*@Nucleus map + CDK2@Nucleus map + p27KIP1*|​pho@Nucleus map map s_s_akt2_s96
  31. s_s_akt2_s96 map s_s_akt2_s95 + p27KIP1*|​pho@Nucleus map
  32. p27KIP1*|​pho@Nucleus map map p27KIP1*|​pho|​pho@Nucleus map
  33. p27KIP1*|​pho@Nucleus map + CRM1*@Nucleus map map CRM1*:​p27KIP1*|​pho@Nucleus map
  34. CRM1*:​p27KIP1*|​pho@Nucleus map map CRM1*:​p27KIP1*|​pho@Cytoplasm map
  35. CRM1*:​p27KIP1*|​pho@Cytoplasm map map CRM1*@Cytoplasm map + p27KIP1*|​pho@Cytoplasm map
  36. p27KIP1*|​pho@Cytoplasm map map p27KIP1*|​pho|​ubi|​ubi|​ubi@Cytoplasm map
  37. p27KIP1*|​pho|​pho@Nucleus map map p27KIP1*|​pho|​pho|​emp|​ubi|​ubi|​ubi@Cytoplasm map
  38. p27KIP1*@Cytoplasm map map p27KIP1*@Nucleus map
  39. s_s_akt2_s124 map (CDK4_6*:​p27KIP1*|​pho|​pho|​pho|​S157_pho)|​active@Nucleus map
  40. (CDK4_6*:​p27KIP1*|​pho|​pho|​pho|​S157_pho)|​active@Nucleus map map G1 phase@Nucleus map

As Catalyser:

  1. E2F1@Nucleus map map E2F1@Nucleus map

  2. c_s761 map CDK4:​CyclinD*@Nucleus map
  3. CDK6:​CyclinD*@Cytoplasm map map CDK6:​CyclinD*@Nucleus map
  4. DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*@Nucleus map map DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*|​pho@Nucleus map
  5. BAF250*:​DP1*:​E2F1:​RB1|​pho@Nucleus map map HDAC1@Nucleus map + BAF250*:​DP1*:​E2F1:​RB1|​pho|​pho@Nucleus map
  6. DP2*:​E2F4:​p107*@Nucleus map map DP2*:​E2F4:​p107*|​pho@Nucleus map
  7. s_s_akt2_s96 map s_s_akt2_s95 + p27KIP1*|​pho@Nucleus map

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