p21CIP1*

Gene p21CIP1* map

Identifiers
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A
CDKN1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:9618481
p21 is regulated by 3 classes of signals that result in arrest of cell growth:
(i) p53 (activated by DNA damage), p73, or the tumor suppressor protein BRCA1.
(ii) Extracellular growth factors acting in a p53-independent mechanism, e.g. TGFB
(iii) Factors that induce cellular differentiation
-Smad4 transactivated the proximal p21 promoter 1.3-fold
-Smad2 transactivated the proximal p21 promoter 3-fold
-Smad2/4 transactivated the proximal p21 promoter 12-fold
-Smad3 transactivated the proximal p21 promoter 25-fold
-Smad3/Smad2 transactivated the proximal p21 promoter 40-fold
-Smad3/Smad4 transactivated the proximal p21 promoter 110-fold
-Smad2/Smad3/Smad4 transactivated the proximal p21 promoter 140-fold
Smad proteins act as Transcriptional Activators via functional interactions with the Transcription factor Sp1
synonym:p21 synonym:CIP1 synonym:WAF1
PMID:19440234
PMID:20673124

gp21CIP1*@Nucleus

References
e_re275( EMT  map ):
PMID:9618481
-Smad4 transactivated the proximal p21 promoter 1.3-fold
-Smad2 transactivated the proximal p21 promoter 3-fold
-Smad2/4 transactivated the proximal p21 promoter 12-fold
-Smad3 transactivated the proximal p21 promoter 25-fold
-Smad3/Smad2 transactivated the proximal p21 promoter 40-fold
-Smad3/Smad4 transactivated the proximal p21 promoter 110-fold
-Smad2/Smad3/Smad4 transactivated the proximal p21 promoter 140-fold
Smad proteins act as Transcriptional Activators via functional interactions with the Transcription factor Sp1
PMID:12545156
Myc represses differentiation-induced p21 expression via Miz-1-dependent interaction with the p21 core promoter
Myc binds the p21 core promoter in vitro through interaction with Miz-1
Myc and Miz-1 interact with the p21 promoter in vivo
PMID:15155580
Snail regulates cell-cycle progression and survival:
Snail regulates components of the early to late G1 transition and the G1/S checkpoint.
Snail represses Cyclin D2 transcription and increases p21/Cip1 transcription.
PMID:17550342
SNAI2 induces p21CIP1 (CDKN1A) expression

gp21CIP1*@Gene compartment

References
c_re926:( Cell cycle  map ) PMID:10030670


Modifications:
In compartment: Gene compartment
  1. gp21CIP1*@Gene compartment map

In compartment: Nucleus

  1. gp21CIP1*@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gp21CIP1*@Nucleus map map rp21CIP1*@Nucleus map

    2. E2F3_alone@Cytoplasm map map gp21CIP1*@Gene compartment map
    3. E2F1_alone@Cytoplasm map map gp21CIP1*@Gene compartment map
    4. gp21CIP1*@Nucleus map map rp21CIP1*@Nucleus map
    5. p53*|​pho@Nucleus map map gp21CIP1*@Nucleus map
    6. gp21CIP1*@Nucleus map map c_s771
    7. STAT1|​unk@Nucleus map map gp21CIP1*@Nucleus map

    As Catalyser:

      Leave a Reply