p21CIP1*

Protein p21CIP1* map

Identifiers
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A
CDKN1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / APOPTOSIS_GENES  map
 Cell cycle  map  / P21CIP  map
 Survival  map  / MAPK  map
 Survival  map  / PI3K_AKT_MTOR  map

References
synonym:p21 synonym:CIP1 synonym:WAF1
Induced by p53.
PMID:10385618, PMID:10498883
Degraded by the ubiquitin-proteasome system.
PMID:9736735
PMID:19440234
PMID:12851486

p21CIP1*@Nucleus

References
c_re178( Cell cycle  map ):
All three Cip/Kip family members direct the accumulation of cylinD-CDK complexes in the nucleus.
PMID:10385618
c_re262( Cell cycle  map ):
Inhibition of PCNA by p21.
PMID:12814430
c_re324:( Cell cycle  map ) PMID:16775416
c_re325:( Cell cycle  map ) PMID:12836612
c_re604( Cell cycle  map ):
Phosphorylation at T145 is catalyzed by the protein serine/threonine kinase Akt
PMID:16775416, PMID:15798220
Phosphorylation of p21 at Thr-145 by AKT-1 induce its cytoplasmic localization.
PMID:11231573

p21CIP1*|​T145_pho@Cytoplasm

References
c_re605( Cell cycle  map ):
Relocalization of p21 from the nucleus to the cytosol
PMID:16775416, PMID:9632134

p21CIP1*|​Thr57_pho@Nucleus

References
c_re1272:( Cell cycle  map ) PMID:15798220

p21CIP1*|​T145_pho@Nucleus

References
c_re604( Cell cycle  map ):
Phosphorylation at T145 is catalyzed by the protein serine/threonine kinase Akt
PMID:16775416, PMID:15798220
Phosphorylation of p21 at Thr-145 by AKT-1 induce its cytoplasmic localization.
PMID:11231573
c_re605( Cell cycle  map ):
Relocalization of p21 from the nucleus to the cytosol
PMID:16775416, PMID:9632134

p21CIP1*|​pho@Cytoplasm

References
s_mpk1_re269( Survival  map ):
P21 is a direct substrate of AKT and this may regulate the subcellular localisation of P21. Phosphorylation of P21 by AKT correlated with its exit from the nucleus and with increased cell cycle progression.
PMID:11882383

p21CIP1*|​pho|​T146_pho@Cytoplasm

References
s_akt1_re188:( Survival  map ) PMID:11756412
s_akt1_re189:( Survival  map ) PMID:19440234

p21CIP1*|​pho@Nucleus

References
s_akt2_re144:( Survival  map ) PMID:11463845 PMID:11756412

p21CIP1*|​pho|​pho@Nucleus

References
s_akt2_re146:( Survival  map ) PMID:11756412


Modifications:
In compartment: Cytoplasm
  1. p21CIP1*@Cytoplasm map

  2. p21CIP1*|​pho@Cytoplasm map
  3. p21CIP1*|​T145_pho@Cytoplasm map
  4. p21CIP1*|​pho|​T146_pho@Cytoplasm map

In compartment: Nucleus

  1. p21CIP1*@Nucleus map

  2. p21CIP1*|​pho@Nucleus map
  3. p21CIP1*|​T145_pho@Nucleus map
  4. p21CIP1*|​Thr57_pho@Nucleus map
  5. p21CIP1*|​pho|​pho@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. CDK4:​CyclinD1*:​p21CIP1*@Cytoplasm map

In compartment: Nucleus

  1. CDK4:​CyclinD*:​p21CIP1*@Nucleus map

  2. CDK6:​CyclinD*:​p21CIP1*@Nucleus map
  3. CDK1|​Thr161_pho:​CyclinB*:​p21CIP1*@Nucleus map
  4. CDK2|​Thr160_pho:​CyclinA*:​p21CIP1*@Nucleus map
  5. CDK2|​Thr160_pho:​CyclinE*:​p21CIP1*@Nucleus map
  6. CDK4_6*:​CyclinD*|​T286_pho:​p21CIP1*|​pho|​pho@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. rp21CIP1*@Nucleus map map p21CIP1*@Cytoplasm map

  2. p21CIP1*@Nucleus map map p21CIP1*|​Thr57_pho@Nucleus map
  3. PCNA@Nucleus map + p21CIP1*@Nucleus map map c_s771
  4. p21CIP1*@Nucleus map + CDK6:​CyclinD*@Nucleus map map CDK6:​CyclinD*:​p21CIP1*@Nucleus map
  5. p21CIP1*@Nucleus map + CDK4:​CyclinD*@Nucleus map map CDK4:​CyclinD*:​p21CIP1*@Nucleus map
  6. CDK2:​CyclinA*@Nucleus map + p21CIP1*@Nucleus map map CDK2|​Thr160_pho:​CyclinA*:​p21CIP1*@Nucleus map
  7. CDK2|​Thr160_pho:​CyclinE*@Nucleus map + p21CIP1*@Nucleus map map CDK2|​Thr160_pho:​CyclinE*:​p21CIP1*@Nucleus map
  8. CDK1|​Thr161_pho:​CyclinB*@Nucleus map + p21CIP1*|​Thr57_pho@Nucleus map map CDK1|​Thr161_pho:​CyclinB*:​p21CIP1*@Nucleus map
  9. p21CIP1*@Nucleus map map p21CIP1*|​T145_pho@Nucleus map
  10. p21CIP1*|​T145_pho@Nucleus map map p21CIP1*|​T145_pho@Cytoplasm map
  11. p21CIP1*@Cytoplasm map + CDK4_6*:​CyclinD1*@Cytoplasm map map CDK4:​CyclinD1*:​p21CIP1*@Cytoplasm map
  12. rp21CIP1*@Nucleus map map p21CIP1*@Cytoplasm map
  13. p21CIP1*@Cytoplasm map map p21CIP1*|​T145_pho@Cytoplasm map
  14. p21CIP1*|​T145_pho@Cytoplasm map map p21CIP1*|​pho|​T146_pho@Cytoplasm map
  15. p21CIP1*|​pho|​T146_pho@Cytoplasm map + Caspase3*@Cytoplasm map map s_s_akt1_s755
  16. c_s771 map p21CIP1*|​pho@Nucleus map
  17. p21CIP1*@Cytoplasm map map c_s771
  18. p21CIP1*|​pho@Nucleus map map p21CIP1*|​pho|​pho@Nucleus map
  19. p21CIP1*|​pho|​pho@Nucleus map + CyclinD*|​T286_pho@Nucleus map + CDK4_6*@Nucleus map map CDK4_6*:​CyclinD*|​T286_pho:​p21CIP1*|​pho|​pho@Nucleus map
  20. CDK4_6*:​CyclinD*|​T286_pho:​p21CIP1*|​pho|​pho@Nucleus map map G1 phase@Nucleus map
  21. c_s771 map p21CIP1*|​pho@Cytoplasm map

As Catalyser:

  1. E2F1@Nucleus map map E2F1@Nucleus map

  2. NFE2L2@Cytoplasm map map NFE2L2|​ubi@Cytoplasm map
  3. c_s761 map CDK4:​CyclinD*@Nucleus map
  4. CDK6:​CyclinD*@Cytoplasm map map CDK6:​CyclinD*@Nucleus map
  5. DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*@Nucleus map map DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*|​pho@Nucleus map
  6. BAF250*:​DP1*:​E2F1:​RB1|​pho@Nucleus map map HDAC1@Nucleus map + BAF250*:​DP1*:​E2F1:​RB1|​pho|​pho@Nucleus map
  7. DP2*:​E2F4:​p107*@Nucleus map map DP2*:​E2F4:​p107*|​pho@Nucleus map

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