p21CIP1*

RNA p21CIP1* map

Identifiers
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 Apoptosis  map  / APOPTOSIS_GENES  map

References
synonym:p21 synonym:CIP1 synonym:WAF1

rp21CIP1*@Nucleus

References
e_re275( EMT  map ):
PMID:9618481
-Smad4 transactivated the proximal p21 promoter 1.3-fold
-Smad2 transactivated the proximal p21 promoter 3-fold
-Smad2/4 transactivated the proximal p21 promoter 12-fold
-Smad3 transactivated the proximal p21 promoter 25-fold
-Smad3/Smad2 transactivated the proximal p21 promoter 40-fold
-Smad3/Smad4 transactivated the proximal p21 promoter 110-fold
-Smad2/Smad3/Smad4 transactivated the proximal p21 promoter 140-fold
Smad proteins act as Transcriptional Activators via functional interactions with the Transcription factor Sp1
PMID:12545156
Myc represses differentiation-induced p21 expression via Miz-1-dependent interaction with the p21 core promoter
Myc binds the p21 core promoter in vitro through interaction with Miz-1
Myc and Miz-1 interact with the p21 promoter in vivo
PMID:15155580
Snail regulates cell-cycle progression and survival:
Snail regulates components of the early to late G1 transition and the G1/S checkpoint.
Snail represses Cyclin D2 transcription and increases p21/Cip1 transcription.
PMID:17550342
SNAI2 induces p21CIP1 (CDKN1A) expression


Modifications:
In compartment: Nucleus
  1. rp21CIP1*@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. gp21CIP1*@Nucleus map map rp21CIP1*@Nucleus map

    2. rp21CIP1*@Nucleus map map p21CIP1*@Cytoplasm map
    3. gp21CIP1*@Nucleus map map rp21CIP1*@Nucleus map
    4. rp21CIP1*@Nucleus map map p21CIP1*@Cytoplasm map

    As Catalyser:

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