p14ARF*

Protein p14ARF* map

Identifiers
cyclin-dependent kinase inhibitor 2A
HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771 GENECARDS:CDKN2A REACTOME:87039 KEGG:1029 ATLASONC:CDKN2aID146 WIKI:CDKN2A
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / HIF1  map
 Cell cycle  map  / APOPTOSIS_ENTRY  map

References
uniprot:Q8N726

p14ARF*@Nucleus

References
a_re449:( Apoptosis  map ) PMID:16508011
a_re457:( Apoptosis  map ) PMID:15989956
a_re671( Apoptosis  map ):
PMID:15199070
ARF binds to and inhibits MYC, in a p53 independent manner. ARF induces MYC localization to nucleolus
a_re1127( Apoptosis  map ):
PMID:19590512
Siva1 and mdm2
PMID:15989956
HUWE1
PMID:19960022
effect of SIRT1 K382-deacetylation
a_re1172( Apoptosis  map ):
PMID:20208519
TRIP12 is a E3 ubiquitin ligase for ARF
MYC, independently of its DNA binding domain, inhibits TRIP12-mediated ARF degradation through direct interaction with TRIP12
Nucleophosmin protects ARF from TRIP12-mediated ubiquitination by targeting it to the nucleolus

p14ARF*|​ubi@Nucleus

References
a_re1172( Apoptosis  map ):
PMID:20208519
TRIP12 is a E3 ubiquitin ligase for ARF
MYC, independently of its DNA binding domain, inhibits TRIP12-mediated ARF degradation through direct interaction with TRIP12
Nucleophosmin protects ARF from TRIP12-mediated ubiquitination by targeting it to the nucleolus

p14ARF*@Nucleolus

References
a_re1390:( Apoptosis  map ) PMID:20208519


Modifications:
In compartment: Nucleolus
  1. p14ARF*@Nucleolus map

In compartment: Nucleus

  1. p14ARF*@Nucleus map

  2. p14ARF*|​ubi@Nucleus map

Participates in complexes:
In compartment: Nucleolus

  1. DP1*:​p14ARF*@Nucleolus map

  2. E2F1:​p14ARF*@Nucleolus map
  3. MDM2:​p14ARF*@Nucleolus map

In compartment: Nucleus

  1. HECTH9*:​p14ARF*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. p14ARF*@Nucleus map map p14ARF*|​ubi@Nucleus map

  2. p14ARF*|​ubi@Nucleus map map degraded
  3. p14ARF*@Nucleus map map p14ARF*@Nucleolus map
  4. rp14ARF*@Nucleus map map p14ARF*@Nucleus map
  5. p14ARF*@Nucleus map + HECTH9*@Nucleus map map HECTH9*:​p14ARF*@Nucleus map
  6. MYC@Nucleus map + p14ARF*@Nucleus map map a_s3238
  7. c_s732 map MDM2:​p14ARF*@Nucleolus map
  8. c_s730 map DP1*:​p14ARF*@Nucleolus map
  9. c_s729 map E2F1:​p14ARF*@Nucleolus map

As Catalyser:

  1. p53*|​S15_pho|​active@Nucleus map map p53*@Nucleus map

  2. CTBP*@Nucleus map map degraded

Leave a Reply