p130*

Protein p130* map

Identifiers
Retinoblastoma-like 2 (p130)
HUGO:RBL2 HGNC:9894 ENTREZ:5934 UNIPROT:Q08999 GENECARDS:RBL2 REACTOME:62850 KEGG:5934 ATLASONC:RBL2ID443 WIKI:RBL2

Maps_Modules
 Cell cycle  map  / CYCLINA  map
 Cell cycle  map  / CYCLINE  map
 Cell cycle  map  / E2F4  map

References
More important in quiescent cells.
PMID:15838516.
22 phophorylation sites in total.
PMID:11157749.
9 phosphorylation sites are CDK-dependants: 8 sites for CYCLIND-CDK4/6 (T401, S413, S639, S662, S672, S1035, S1044, S1080) and 1 site for CYCLINE-CDK2 (S1112).
PMID:12006580
Shuttling of p130 between the nucleus and cytoplasm
PMID:11756542

p130*|​pho@Nucleus

References
c_re290( Cell cycle  map ):
PMID:12006580
PMID:15769944
c_re197( Cell cycle  map ):
Degradation via the ubiquitin-proteasome system.
PMID:10773440
Degradation via SCF(SKP2) (=SKP1-Culin1-SKP2)
PMID:12717421
c_re1274( Cell cycle  map ):
p130 binds to and inhibits CYCLINA-CDK2, independantly of its phosphorylation state.
PMID:15456871, PMID:12006580, PMID:11237530
c_re1276( Cell cycle  map ):
p130 binds to and inhibits CYCLINE-CDK2, independantly of its phosphorylation state.
PMID:15456871
PMID:11237530


Modifications:
In compartment: Cytoplasm
  1. p130*@Cytoplasm map

In compartment: Nucleus

  1. p130*|​pho@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. DP2*:​E2F4:​p130*@Cytoplasm map

In compartment: Nucleus

  1. DP2*:​E2F4:​p130*@Nucleus map

  2. CDK2:​CyclinA*:​p130*|​pho@Nucleus map
  3. CDK2|​Thr160_pho:​CyclinE*:​p130*|​pho@Nucleus map
  4. DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*@Nucleus map
  5. DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*|​pho@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. p130*|​pho@Nucleus map + CDK2:​CyclinA*@Nucleus map map CDK2:​CyclinA*:​p130*|​pho@Nucleus map

  2. p130*|​pho@Nucleus map + CDK2|​Thr160_pho:​CyclinE*@Nucleus map map CDK2|​Thr160_pho:​CyclinE*:​p130*|​pho@Nucleus map
  3. p130*|​pho@Nucleus map map degraded
  4. DP2*:​E2F4@Cytoplasm map + p130*@Cytoplasm map map DP2*:​E2F4:​p130*@Cytoplasm map
  5. c_s680 + DP2*:​E2F4:​p130*@Nucleus map + SUV39H1@Nucleus map map DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*@Nucleus map
  6. DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*@Nucleus map map DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*|​pho@Nucleus map
  7. DP2*:​E2F4:​SIN3B:​SUV39H1:​p130*|​pho@Nucleus map map p130*|​pho@Nucleus map + HDAC1@Nucleus map + SIN3B@Nucleus map + SUV39H1@Nucleus map + DP2*:​E2F4@Nucleus map
  8. DP2*:​E2F4:​p130*@Cytoplasm map map DP2*:​E2F4:​p130*@Nucleus map

As Catalyser:

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