p110*:p85*

Complex p110*:p85* map


Complex composition:

  1. p110* map
  2. p85* map




p110*:​p85*@Cytoplasm

Identifiers
NAME:p110*:p85*

Maps_Modules
 Survival  map  / HEDGEHOG  map

References
s_shh3_re15( Survival  map ):
PMID:11801735
PMID:19082481
s_akt1_re11( Survival  map ):
PMID:15584861
PMID:10648629

Confidence
REF=3 FUNC=0

p110*:​p85*@Cytoplasm

Identifiers
NAME:p110*:p85*

Maps_Modules
 Survival  map  / PI3K_AKT_MTOR  map

References
PMID:16847462
Class IA PI3K is a heterodimer that consists of a p85 regulatory subunit and a p110 catalytic subunit. Three genes PIK3R1 PIK3R2 and PIK3R3 encode the p85α p85β and p55γ isoforms of the p85 regulatory subunit respectively. The PIK3R1 gene also gives rise to two shorter isoforms p55α and p50α through alternative transcription-initiation sites. The class IA p85 regulatory isoforms have a common core structure consisting of a p110-binding domain (also called the inter-SH2 domain) flanked by two Src-homology 2 (SH2) domains. The two longer isoforms p85α and p85β also have an extended N-terminal region (dashed outline) containing an Src-homology 3 (SH3) domain and a BCR homology (BH) domain flanked by two proline-rich (P) regions.
PMID:19568798
PI3-Ks can be activated through several mechanisms. The SH2 domains in the p85 regulatory subunit of class Ia PI3- Ks have a high affinity for phosphorylated tyrosine residues found in activated growth factor RTKs and binding of the regulatory subunit to this motif activates PI3-KPhosphoinositide-3-kinase class I a
Identifiers_end
s_akt1_re2( Survival  map ):
PMID:12040186
PMID:14585353
s_akt1_re6( Survival  map ):
PMID:15534002
PMID:9779982
s_s_akt1_re2( Survival  map ):
s_s_akt1_re6( Survival  map ):

Confidence
REF=2 FUNC=4


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. p110*:​p85*@Cytoplasm map

  2. p110*:​p85*@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. p110*:​p85*@Cytoplasm map + s_s_akt1_s53 + PI3,4,5-P3@Lipid Raft map + RTK*@Cytoplasm map + GF@default map + RAS*@Cytoplasm map + GAB1|​Y977_pho|​Y989_pho@Cytoplasm map map GAB1|​Y977_pho|​Y989_pho:​GF:​GRB2:​PI3,4,5-P3:​RAS*:​RTK*|​pho|​pho|​hm2:​SOS*:​p110*:​p85*@Lipid Raft map

  2. GF:​RTK*|​pho|​pho|​hm2@Lipid Raft map + p110*:​p85*@Cytoplasm map map GF:​RTK*|​pho|​pho|​hm2:​p110*:​p85*@Lipid Raft map
  3. p110*:​p85*@Cytoplasm map + RAS*@Cytoplasm map map RAS*:​p110*:​p85*@Lipid Raft map
  4. C-FES*|​Y713_pho|​Y811_pho|​hm2|​active@Cytoplasm map + p110*:​p85*@Cytoplasm map map C-FES*|​Y713_pho|​Y811_pho|​hm2:​p110*:​p85*@Cytoplasm map

As Catalyser:

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