Occludin*:PARD6A:TGFBR1

Complex Occludin*:PARD6A:TGFBR1 map


Complex composition:

  1. TGFBR1 map
  2. PARD6A map
  3. Occludin* map




Occludin*:​PARD6A:​TGFBR1|​hm2@Cytoplasm

Identifiers
NAME:Occludin*:PARD6A:TGFBR1

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CELL_CELL_ADHESIONS  map
 EMT  map  / TIGHT_JUNCTIONS  map

References
e_re340( EMT  map ):
PMID:15761153
Occludin is a structural component of tight junctions that is associated with the cell polarity network.
Occludin regulates TGFBR1 localization for efficient TGFB-dependent dissolution of tight junctions during EMT
Interaction of endogenous OCLN with endogenous TGFBR1 was not modulated by TGFB
but its association with the TGFBR2 increased in a TGFB-dependent manner
PMID:15761148
TGFBR1 localizes with ZO-1 on the cellular apical aspect together with PARD6A and they are situated apically to endogenous E-cadherin
After stimulation by TGFB, TGFBR2 is redistributed to the tight junctions, where it localizes with both TGFBR1 and ZO-1.

Confidence
REF=2 FUNC=5


Modifications:
Participates in complexes:
In compartment: Cytoplasm
  1. Occludin*:​PARD6A:​TGFBR1|​hm2@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. PARD6A@Cytoplasm map + TGFBR1|​hm2@Cytoplasm map + Occludin*@Cytoplasm map map Occludin*:​PARD6A:​TGFBR1|​hm2@Cytoplasm map

  2. Occludin*:​PARD6A:​TGFBR1|​hm2@Cytoplasm map + TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytoplasm map map Occludin*:​PARD6A:​TGFB1|​hm2:​TGFBR1|​hm2:​TGFBR2|​hm2@Cytoplasm map

As Catalyser:

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