Nischarin binds preferentially to the cytoplasmic tail of ITGA5 subunit ti inhibit cell migration.
Nischarin is not found in focal adhesion sites.
Once integrins enter into adhesion sites, Nischarin is released, allowing it to bind to the activated PAK1 in order to inactive PAK1..
This binding is enhaced by active Rac1.
The ability of Nischarin to inhibit PAK1 is related to its ability to inhibit cell motility.
Participates in complexes:
In compartment: Cytoplasm
Participates in reactions:
As Reactant or Product:
- PAK1@Cytoplasm + NISCH@Nucleus → NISCH:PAK1@Cytoplasm
- NISCH:PAK1@Cytoplasm → Cell migration@Cytoplasm