NISCH

Protein NISCH map

Identifiers
Nischarin
HUGO:NISCH HGNC:18006 ENTREZ:11188 UNIPROT:Q9Y2I1 GENECARDS:NISCH KEGG:11188 ATLASONC:GC_NISCH WIKI:NISCH

Maps_Modules
 EMT  map  / EMT_REGULATORS  map
 EMT  map  / CYTOSKELETON_POLARITY  map

References
PMID:11121431
PMID:15157156
PMID:15229651
Nischarin binds preferentially to the cytoplasmic tail of ITGA5 subunit ti inhibit cell migration.
Nischarin is not found in focal adhesion sites.
Once integrins enter into adhesion sites, Nischarin is released, allowing it to bind to the activated PAK1 in order to inactive PAK1..
This binding is enhaced by active Rac1.
The ability of Nischarin to inhibit PAK1 is related to its ability to inhibit cell motility.

NISCH@Nucleus

References
e_re963( EMT  map ):
PMID:11121431
PMID:15157156
PMID:15229651
Nischarin binds preferentially to the cytoplasmic tail of ITGA5 subunit ti inhibit cell migration.
Nischarin is not found in focal adhesion sites.
Once integrins enter into adhesion sites, Nischarin is released, allowing it to bind to the activated PAK1 in order to inactive PAK1..
This binding is enhaced by active Rac1.
The ability of Nischarin to inhibit PAK1 is related to its ability to inhibit cell motility.


Modifications:
In compartment: Nucleus
  1. NISCH@Nucleus map

Participates in complexes:
In compartment: Cytoplasm

  1. NISCH:​PAK1@Cytoplasm map

  2. ITGA5:​NISCH@Cytoplasm map

Participates in reactions:
As Reactant or Product:

  1. ITGA5@Cytoplasm map + NISCH@Nucleus map map ITGA5:​NISCH@Cytoplasm map

  2. PAK1@Cytoplasm map + NISCH@Nucleus map map NISCH:​PAK1@Cytoplasm map
  3. NISCH:​PAK1@Cytoplasm map map Cell migration@Cytoplasm map

As Catalyser:

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