NFKB1

Protein NFKB1 map

Identifiers
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
HUGO:NFKB1 HGNC:7794 ENTREZ:4790 UNIPROT:P19838 GENECARDS:NFKB1 REACTOME:57855 KEGG:4790 ATLASONC:NFKB1ID323 WIKI:NFKB1

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map
 Apoptosis  map  / TNF_RESPONSE  map

NFKB1@Nucleus

References
a_re1379:( Apoptosis  map ) reactionType:is.a
a_re134( Apoptosis  map ):
PMID:7834749
by p53
PMID:15613549
in HEK 293, by NFkB, upon expression of LMP1 protein (from EBV). More precisely, p65/p50 dimer inhibits BAX promoter activity whereas p50/p50 dimer is actually an transcriptional activator or BAX. However p65 has to be inhibited to see p50/p50 mediated activation of BAX
PMID:12676992
in MEF double knocked out by CTBP1 and CTBP2 (RT-PCR)
a_re155( Apoptosis  map ):
PMID:18490439
ENO1 gene products interact with NOTCH1 intracellular domain, thus competing with YY1, to repress MYC expression
PMID:19219071
MYC regulation by FUBP1
PMID:2191300
in WEHI 231 murine B-lymphoma cells, by NFkappaB
a_re189( Apoptosis  map ):
PMID:7508926
in murine RAW 264.7 macrophage cell line, by NFKB
PMID:7500013
in murine macrophage derived from C57BL/6 mice and transformed with J2 (v-raf1v-myc) recombinant retrovirus, by HIF1
PMID:9486205
in rat lung epithelia, by hypoxia
in bovine pulmonary artery endothelial cells, HIF1 regulates the murine iNOS promoter (supershifted EMSA + gene reporter)
a_re190( Apoptosis  map ):
PMID:19211554
in PC-3 human prostate cancer cell line by HIF, transactivation of the promoter (ChIP, EMSA, reporter gene assay)
PMID:10435632
in murine immortalized bone marrow-derived pro-B-cell BA/F3, by STAT5 upon IL3
PMID:10428780 AND PMID:10428030
in murine erythroleukemia HCD-57 cells, by STAT5 upon EPO (HGNC:3415) treatment
PMID:11756417
in UT-7/TPO human TPO-dependent megakaryocytic cell line, by STAT5 and NF-kappaB, upon TPO
a_re203( Apoptosis  map ):
PMID:1829648
in human monocytes
PMID:8096091
in Jurkat
a_re205( Apoptosis  map ):
PMID:12208876
in Hodgkin and Reed-Sternberg cells
a_re207( Apoptosis  map ):
PMID:17438126
in murine C2C12 myoblast cells, in murine 10T1/2 fibroblast cells, in human 293T cells
a_re209( Apoptosis  map ):
PMID:8051093
in Hela cells
a_re211( Apoptosis  map ):
PMID:15102937
in Hela
a_re213( Apoptosis  map ):
PMID:9294162
PMID:9733516
in HT1080, upon TNF, blocked by the expression of the IkBalpha super-repressor form
a_re215( Apoptosis  map ):
PMID:11704864
in LNCaP human prostate cancer cell line
PMID:11313951
transrepression by p53
a_re217( Apoptosis  map ):
PMID:14627988
in mouse macrophages, by REL (HGNC:9954)
a_re218:( Apoptosis  map ) PMID:15537542
a_re220( Apoptosis  map ):
PMID:10049356
in mouse B cells, by c-Rel
a_re222( Apoptosis  map ):
PMID:17724475
a_re224( Apoptosis  map ):
PMID:18393939
in HEK293
PMID:17272744
in human pulmonary artery smooth muscle cells
a_re226( Apoptosis  map ):
PMID:1332946
in BL41 human Burkit’s lymphoma B cells upon infection with EBV
a_re228( Apoptosis  map ):
PMID:19289499
in Jurkat, in HEK293, RELA dependent upregulation of BECN1
a_re230( Apoptosis  map ):
PMID:15766528
in murine fibroblasts, by IKKbeta
PMID:10492402
TNF or IL1 induction of cloned SOD2 full gene requires an intronic NFkB site
PMID:18280257
in human neuroblastoma by NFkB, upon all-trans-retinoic acid (ATRA)
PMID:12239572
in DLD-1 human colon carcinoma cells upon 4OHT mediated activation of ectopic an FOXO3-ER
in MEFs upon lentiviral expression of FOXO3 or FOXO4
in 293T upon LY294002, blocked by expression of a dominant negative FOXO3
a_re232( Apoptosis  map ):
PMID:15317858
in rat PC12 cells pheochromocytoma cells, upon activation of a ER-AKT1 fusion protein by 4OHT
a_re309:( Apoptosis  map ) PMID:17435549
a_re311( Apoptosis  map ):
PMID:19747488
in HepG2, by NFkB, upon copper exposure
PMID:18761713
in rat cortical neurons, by NFE2L2
PMID:19027064
in mouse lung, by NFE2L2
proposed also in human, and deregulation in patients with chronic obstructive pulmonary disorder
a_re314( Apoptosis  map ):
PMID:19706769
in primary foreskin fibroblasts exposed to TNF, G0S2 identified as the most potently induced gene (cDNA microarray). Its expression is confirmed and shown to be abrogated following infection with an Ad-virus encoding an NF-kB super-repressor (RT-PCR).
a_re1144( Apoptosis  map ):
PMID:11359904
by NFkB
PMID:15367674
by MYC


Modifications:
In compartment: Cytoplasm
  1. NFKB1@Cytoplasm map

In compartment: Nucleus

  1. NFKB1@Nucleus map

Participates in complexes:

    Participates in reactions:
    As Reactant or Product:

    1. NFKB1@Cytoplasm map map NFKB1_p50*@Cytoplasm map

    2. NFKB1_p50*:​RELA@Nucleus map map NFKB1@Nucleus map

    As Catalyser:

    1. gCFLAR@Nucleus map map rCFLAR@Nucleus map

    2. gBIRC2@Nucleus map map rBIRC2@Nucleus map
    3. gBAX@Nucleus map map rBAX@Nucleus map
    4. gMYC@Nucleus map map rMYC@Nucleus map
    5. gNOS2@Nucleus map map rNOS2@Nucleus map
    6. gBCL2-XL*@Nucleus map map rBCL2-XL*@Nucleus map
    7. gNFKBIA@Nucleus map map rNFKBIA@Nucleus map
    8. gSTAT5A@Nucleus map map rSTAT5A@Nucleus map
    9. gYY1@Nucleus map map rYY1@Nucleus map
    10. gp53*@Nucleus map map rp53*@Nucleus map
    11. gCTSB@Nucleus map map rCTSB@Nucleus map
    12. gBIRC3@Nucleus map map rBIRC3@Nucleus map
    13. gBCL2@Nucleus map map rBCL2@Nucleus map
    14. gE2F3@Nucleus map map rE2F3A*@Nucleus map
    15. gFTH1@Nucleus map map rFTH1@Nucleus map
    16. gBCL2A1@Nucleus map map rBCL2A1@Nucleus map
    17. gHSP90AA1@Nucleus map map rHSP90AA1@Nucleus map
    18. gHIF1A@Nucleus map map rHIF1A@Nucleus map
    19. gTNFAIP3@Nucleus map map rTNFAIP3@Nucleus map
    20. gBECN1@Nucleus map map rBECN1@Nucleus map
    21. gSOD2@Nucleus map map rSOD2@Nucleus map
    22. gSOD1@Nucleus map map rSOD1@Nucleus map
    23. gXIAP@Nucleus map map rXIAP@Nucleus map
    24. gSRXN1@Nucleus map map rSRXN1@Nucleus map
    25. gG0S2@Nucleus map map rG0S2@Nucleus map

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