NFE2L2

Protein NFE2L2 map

Identifiers
nuclear factor (erythroid-derived 2)-like 2
HUGO:NFE2L2 HGNC:7782 ENTREZ:4780 UNIPROT:Q16236 GENECARDS:NFE2L2 KEGG:4780 ATLASONC:GC_NFE2L2 WIKI:NFE2L2

Maps_Modules
 Apoptosis  map  / APOPTOSIS_GENES  map

References
NOTE: * means activated form

NFE2L2@Cytoplasm

References
a_re416( Apoptosis  map ):
PMID:19560419
CDKN1A interacts directly with NFE2L2, thus competing with KEAP1 binding

NFE2L2|​ubi@Cytoplasm

References
a_re416( Apoptosis  map ):
PMID:19560419
CDKN1A interacts directly with NFE2L2, thus competing with KEAP1 binding

NFE2L2@Nucleus

References
a_re418:( Apoptosis  map ) reactionType:is.a
a_re311( Apoptosis  map ):
PMID:19747488
in HepG2, by NFkB, upon copper exposure
PMID:18761713
in rat cortical neurons, by NFE2L2
PMID:19027064
in mouse lung, by NFE2L2
proposed also in human, and deregulation in patients with chronic obstructive pulmonary disorder
a_re869( Apoptosis  map ):
PMID:10874044
in MCF7 by NFE2L2, upon cadmium exposure
PMID:10821856
in mouse primary peritoneal macrophages, by NFE2L2
PMID:12356737
by BACH1
PMID:12511571
in A549 by BACH1 upon hypoxia
a_re1006( Apoptosis  map ):
PMID:16219762
in PC12 by NFE2L2 upon 4-HNE
PMID:15521073
in bovine arterial endothelial cells, by NFE2L2, upon cadmium
PMID:17512463
in mouse photoreceptor-derived 661W cells, by NFE2L2, upon 4-HNE
a_re1009( Apoptosis  map ):
PMID:11279008
in K562 human myelogenous leukaemia line, by NFE2L2, upon hemin
a_re1014( Apoptosis  map ):
PMID:11909699
in HepG2
a_re1017( Apoptosis  map ):
PMID:10441483
in vitro with HepG2 nuclear extracts for gel (super)shift assay


Modifications:
In compartment: Cytoplasm
  1. NFE2L2@Cytoplasm map

  2. NFE2L2|​ubi@Cytoplasm map

In compartment: Nucleus

  1. NFE2L2@Nucleus map

  2. NFE2L2@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. NFE2L2:​small~MAF*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. NFE2L2@Nucleus map + small~MAF*@Nucleus map map NFE2L2:​small~MAF*@Nucleus map

  2. NFE2L2@Cytoplasm map map NFE2L2|​ubi@Cytoplasm map
  3. NFE2L2|​ubi@Cytoplasm map map degraded
  4. NFE2L2:​small~MAF*@Nucleus map map NFE2L2@Nucleus map
  5. NFE2L2@Cytoplasm map map NFE2L2@Nucleus map

As Catalyser:

  1. gTXNRD1@Nucleus map map rTXNRD1@Nucleus map

  2. gTXN@Nucleus map map rTXN@Nucleus map
  3. gGCLC@Nucleus map map rGCLC@Nucleus map
  4. gGCLM@Nucleus map map rGCLM@Nucleus map
  5. gSRXN1@Nucleus map map rSRXN1@Nucleus map
  6. gHMOX1@Nucleus map map rHMOX1@Nucleus map
  7. gPRDX1@Nucleus map map rPRDX1@Nucleus map

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