NFAT1*

Protein NFAT1* map

Identifiers
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2

Maps_Modules
 Survival  map  / WNT_NON_CANONICAL  map

References
NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family; 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328.
PMID:11030334
NFAT5 activity is not regulated by phosphorylation but osmotic stress
PMID:11402342

NFAT1*@Cytoplasm

References
s_wnc2_re70( Survival  map ):
Only NFAT1 is sensitive to cleavage by caspase-3 at consensus sites: DELD and/or DVLD.
PMID:16455648

NFAT1*@Nucleus

References
s_wnc3_re16( Survival  map ):
Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a “?”. Lys684 is targeted firstly, followed by Lys897.
PMID:15117942
s_wnc3_re23( Survival  map ):
NFATs are ADP-ribosylated. Also NFAT2 @E427, NFAT3 @E418, NFAT4@E432
There is not special character to indicated this PTM, I have used glycosylation instead.
PMID:18299389, PMID:18078995
s_wnc3_re26:( Survival  map ) PMID:12453415

NFAT1*|​unk@Nucleus

References
s_wnc3_re16( Survival  map ):
Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a “?”. Lys684 is targeted firstly, followed by Lys897.
PMID:15117942

NFAT1*|​unk|​unk@Nucleus

Maps_Modules
 Survival  map  / WNT_NON_CANONICAL  map

References
Sumoylation of NFAT1 enhances nuclear retention and increases transcription.
PMID:15117942
s_wnc3_re17( Survival  map ):
Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a “?”. Lys684 is targeted firstly, followed by Lys897.
s_wnc3_re5:( Survival  map ) PMID:15657420
s_wnc3_re22:( Survival  map ) To indicate that sumoylated NFAT1 forms as well NFAT/AP comlexes.
s_s_wnc3_re17( Survival  map ):

NFAT1*|​gly@Nucleus

References
s_wnc3_re23( Survival  map ):
NFATs are ADP-ribosylated. Also NFAT2 @E427, NFAT3 @E418, NFAT4@E432
There is not special character to indicated this PTM, I have used glycosylation instead.
PMID:18299389, PMID:18078995
s_wnc3_re5:( Survival  map ) PMID:15657420
s_wnc3_re24:( Survival  map ) This isoform of NFAT1 forms also NFAT/AP-1 complexes.


Modifications:
In compartment: Cytoplasm
  1. NFAT1*@Cytoplasm map

In compartment: Nucleus

  1. NFAT1*@Nucleus map

  2. NFAT1*|​gly@Nucleus map
  3. NFAT1*|​unk@Nucleus map
  4. NFAT1*|​unk|​unk@Nucleus map

Participates in complexes:
In compartment: Nucleus

  1. HDAC*:​NFAT1*@Nucleus map

Participates in reactions:
As Reactant or Product:

  1. NFAT*|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho|​pho@Cytoplasm map map NFAT1*@Cytoplasm map

  2. NFAT1*@Nucleus map map NFAT1*|​unk@Nucleus map
  3. NFAT1*|​unk@Nucleus map map NFAT1*|​unk|​unk@Nucleus map
  4. NFAT1*|​unk|​unk@Nucleus map map NFAT*@Nucleus map
  5. NFAT1*@Nucleus map map NFAT1*|​gly@Nucleus map
  6. NFAT1*|​gly@Nucleus map map NFAT*@Nucleus map
  7. NFAT1*@Nucleus map + HDAC*@Nucleus map map HDAC*:​NFAT1*@Nucleus map

As Catalyser:

  1. gMYC@Nucleus map map rMYC@Nucleus map

  2. gCDK4@Nucleus map map rCDK4@Nucleus map
  3. gAP-1_ARRE binding sites*@Nucleus map + JUN@Nucleus map + FOS@Nucleus map + NFAT*@Nucleus map map AP-1_ARRE binding sites*:​FOS:​JUN:​NFAT*@Nucleus map

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